Primary biliary cirrhosis laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Laboratory Findings

To diagnose PBC, distinctions should be established from other conditions with similar symptoms, such as autoimmune hepatitis or primary sclerosing cholangitis (PSC).

Diagnostic blood tests include:

• Deranged liver function tests (high alkaline phosphatase, elevated AST, ALT)
• Presence of certain antibodies: antimitochondrial antibody antinuclear antibodies like anti-glycoprotein-210 antibodies, anti-centromere antibodies, anti-sp100. (the M2-IgG antimitochondrial antibody is the most specific test)