Purpura pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
Purpura is a common and unspecific symptom, however the underlying mechanism commonly involves one of the following; | Purpura is a common and unspecific symptom, however the underlying mechanism commonly involves one of the following; | ||
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**[[Disseminated intravascular coagulation]] (DIC) | **[[Disseminated intravascular coagulation]] (DIC) | ||
There are also cases of psychogenic purpura described in the medical literature,<ref name="pmid10069314">{{cite journal |author=Anderson JE, DeGoff W, McNamara M |title=Autoerythrocyte sensitization (psychogenic purpura): a case report and review of the literature |journal=Pediatric emergency care |volume=15 |issue=1 |pages=47-8 |year=1999 |pmid=10069314 |doi=}}</ref> some claimed to be due to "autoerythrocyte sensitization". Other studies<ref name="pmid8340191">{{cite journal |author=Lotti T, Benci M, Sarti MG, Teofoli P, Senesi C, Bonan P, et al. |title=Psychogenic purpura with abnormallt cutaney increased tPA dependeny |journous fibrinolytic activital=Int J Dermatol |volume=32| issue=7 |pages=521-3 |year=1993 |pmid=8340191 |doi=}}</ref> suggest, that local (cutaneous) activity of [[tPA]] can be increased in psychogenic purpura, leading to substantial amounts of localized plasmin activity, rapid degradation of fibrin clots, and resultant bleeding. | There are also cases of psychogenic purpura described in the medical literature,<ref name="pmid10069314">{{cite journal |author=Anderson JE, DeGoff W, McNamara M |title=Autoerythrocyte sensitization (psychogenic purpura): a case report and review of the literature |journal=Pediatric emergency care |volume=15 |issue=1 |pages=47-8 |year=1999 |pmid=10069314 |doi=}}</ref> some claimed to be due to "autoerythrocyte sensitization". Other studies<ref name="pmid8340191">{{cite journal |author=Lotti T, Benci M, Sarti MG, Teofoli P, Senesi C, Bonan P, et al. |title=Psychogenic purpura with abnormallt cutaney increased tPA dependeny |journous fibrinolytic activital=Int J Dermatol |volume=32| issue=7 |pages=521-3 |year=1993 |pmid=8340191 |doi=}}</ref> suggest, that local (cutaneous) activity of [[tPA]] can be increased in psychogenic purpura, leading to substantial amounts of localized plasmin activity, rapid degradation of [[fibrin]] clots, and resultant bleeding. | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Needs overview]] | [[Category:Needs overview]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
Revision as of 15:30, 23 April 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Pathophysiology
Purpura is a common and unspecific symptom, however the underlying mechanism commonly involves one of the following;
- Platelet disorders
- Primary thrombocytopenic purpura
- Secondary thrombocytopenic purpura
- Vascular disorders
- Microvascular injury, as seen in senile (old age) purpura, when blood vessels are more easily damaged
- Hypertensive states
- Deficient vascular support
- Vasculitis, as in the case of Henoch-Schönlein purpura
- Coagulation disorders
There are also cases of psychogenic purpura described in the medical literature,[1] some claimed to be due to "autoerythrocyte sensitization". Other studies[2] suggest, that local (cutaneous) activity of tPA can be increased in psychogenic purpura, leading to substantial amounts of localized plasmin activity, rapid degradation of fibrin clots, and resultant bleeding.
References
- ↑ Anderson JE, DeGoff W, McNamara M (1999). "Autoerythrocyte sensitization (psychogenic purpura): a case report and review of the literature". Pediatric emergency care. 15 (1): 47–8. PMID 10069314.
- ↑ Lotti T, Benci M, Sarti MG, Teofoli P, Senesi C, Bonan P; et al. (1993). "Psychogenic purpura with abnormallt cutaney increased tPA dependeny". 32 (7): 521–3. PMID 8340191. Unknown parameter
|journous fibrinolytic activital=ignored (help)