Lactic acidosis causes: Difference between revisions

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Revision as of 19:37, 22 July 2013

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Lactic acidosis is one of the most common causes of high anion gap metabolic acidosis and is usually associated with a serum lactate levels above 4 mmol/L. Reduced oxygen tension shunts glycolysis towards pyruvate production, which in turn leads to lactate accumulation since pyruvate can no longer undergo aerobic metabolism.

Causes

Life Threatening Causes

Common Causes

Causes by Organ System

Cardiovascular	Cardiac arrest, cardiac catheterization, cardiomyopathy, heart failure, hemorrhage, hypoperfusion, hypovolemia, multiple organ dysfunction syndrome, myocardial infarction, shock, ST elevation myocardial infarction complications
Chemical/Poisoning	Alcoholism, carbon monoxide poisoning, contrast medium, cyanide poisoning, ethanol, intravenous pyelogram, isopropyl alcohol
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Abacavir, adefovir, atenolol, biguanide, buformin, didanosine, emtricitabine, entecavir, lamivudine, linezolid, metformin, paracetamol, phenformin, reye's syndrome, salicylate intoxication, stavudine, strychnine, telbivudine, tenofovir, zalcitabine
Ear Nose Throat	No underlying causes
Endocrine	Diabetic nephropathy, hypoglycemia, latent autoimmune diabetes, metabolic syndrome
Environmental	No underlying causes
Gastroenterologic	Acute liver failure, intestinal ischemia, liver failure, mesenteric ischemia, short bowel syndrome
Genetic	Fructose intolerance, fructose-1-phosphate aldolase deficiency, fructose-1,6-diphosphatase deficiency, glycogen storage disease, holocarboxylase synthase deficiency, MELAS, MERRF, mitochondrial myopathy, pyruvate carboxylase deficiency, pyruvate dehydrogenase deficiency, von Gierke disease
Hematologic	Anemia, Burkitt's lymphoma, leukemia, non Hodgkin's lymphoma
Iatrogenic	Cardiac catheterization
Infectious Disease	Acquired immune deficiency syndrome, sepsis
Musculoskeletal/Orthopedic	No underlying causes
Neurologic	Ethylmalonic encephalopathy, grand mal seizure, seizures
Nutritional/Metabolic	Ariboflavinosis, beriberi heart disease, fructose intolerance, fructose-1-phosphate aldolase deficiency, fructose-1,6-diphosphatase deficiency, pyruvate carboxylase deficiency, pyruvate dehydrogenase deficiency, thiamine deficiency
Obstetric/Gynecologic	fetal distress, oligohydramnios,
Oncologic	burkitt's lymphoma, cancer, leukemia, non Hodgkin's lymphoma, pheochromocytoma,
Ophthalmologic	No underlying causes
Overdose/Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	Asthma, hypercapnia, hypoxia, pulmonary edema, respiratory failure
Renal/Electrolyte	Diabetic nephropathy, hemofiltration, renal failure
Rheumatology/Immunology/Allergy	Latent autoimmune diabetes
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	Bacterial overgrowth of small intestine, chronic fatigue syndrome, coenzyme q10 deficiency, exercise, glycogen storage disease, hypothermia, idiopathic, malignant hyperpyrexia, mitochondrial toxicity, smoke inhalation

Causes by Organ System developed by WikiDoc.org, Copyleft 2013

Causes in Alphabetical Order

References

Template:WikiDoc Sources

@@ Line 30: / Line 30: @@
 {|style="width:80%; height:100px" border="1"
 |style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
-|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" |ST Elevation [[Myocardial Infarction]] Complications , [[Shock]] , [[Heart diseases]] , [[Cardiomyopathy ]] , [[Cardiac arrest ]] , [[Beriberi Heart Disease]] , Acute [[pulmonary edema]]
+|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | [[Cardiac arrest]],  [[cardiac catheterization]],  [[cardiomyopathy]],  [[heart failure]],  [[hemorrhage]],  [[hypoperfusion]],  [[hypovolemia]],  [[multiple organ dysfunction syndrome]],  [[myocardial infarction]],  [[shock]],  [[ST elevation myocardial infarction complications]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Chemical/Poisoning'''
-|bgcolor="Beige"|[[Isopropyl alcohol]] , [[Ethanol]] , [[Cyanide]] intoxication  , Crotalidae snake [[poisoning ]], Copperhead snake [[poisoning ]], [[Contrast medium]] , Complications During and Following [[Cardiac Catheterization]], [[Carbon monoxide poisoning ]] ,  [[Alcoholism ]]
+|bgcolor="Beige"| [[Alcoholism]],  [[carbon monoxide poisoning]],  [[contrast medium]],  [[cyanide poisoning]],  [[ethanol]],  [[intravenous pyelogram]],  [[isopropyl alcohol]]
 |-
 |-bgcolor="LightSteelBlue"
@@ Line 46: / Line 46: @@
 |-bgcolor="LightSteelBlue"
 | '''Drug Side Effect'''
-|bgcolor="Beige"|[[Zalcitabine]] , [[Tenofovir ]] , [[Telbivudine ]] , [[Succinyl-CoA]] synthetase deficiency , [[Stavudine]] , [[Phenformin]] , [[Paracetamol]] , [[Metformin]] , [[Linezolid]] , [[Lamivudine ]] , [[Glyburide and Metformin ]] , [[Entecavir ]] , [[Emtricitabine]] , [[Didanosine]] , [[Buformin]] , [[Biguanide]] , [[Atenolol]] , [[Ariboflavinosis]] , [[Adefovir ]] , [[Abacavir]] , [[Abacavir]]
+|bgcolor="Beige"| [[Abacavir]],  [[adefovir]],  [[atenolol]],  [[biguanide]],  [[buformin]],  [[didanosine]],  [[emtricitabine]],  [[entecavir]],  [[lamivudine]],  [[linezolid]],  [[metformin]],  [[paracetamol]],  [[phenformin]],  [[reye's syndrome]],  [[salicylate intoxication]],  [[stavudine]],  [[strychnine]],  [[telbivudine]],  [[tenofovir]],  [[zalcitabine]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Ear Nose Throat'''
 |bgcolor="Beige"| No underlying causes
 |-
 |-bgcolor="LightSteelBlue"
 | '''Endocrine'''
-|bgcolor="Beige"|[[Pheochromocytoma ]] , [[Latent autoimmune diabetes]] , [[Hypoglycemia]] , [[Diabetic nephropathy]] , [[Diabetes mellitus]]
+|bgcolor="Beige"| [[Diabetic nephropathy]],  [[hypoglycemia]],  [[latent autoimmune diabetes]],  [[metabolic syndrome]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Environmental'''
-|bgcolor="Beige"|[[Smoke inhalation ]]
+|bgcolor="Beige"| No underlying causes
 |-
 |-bgcolor="LightSteelBlue"
 | '''Gastroenterologic'''
-|bgcolor="Beige"|[[Short bowel syndrome]] , [[Mesenteric ischemia]] , [[Liver disease]] , [[Intestinal ischaemia]] , [[Hepatic failure]] , [[Bacterial]] overgrowth of [[small intestine]] , [[Acute liver failure]]
+|bgcolor="Beige"| [[Acute liver failure]],  [[intestinal ischemia]],  [[liver failure]],  [[mesenteric ischemia]],  [[short bowel syndrome]]
+|-
 |-bgcolor="LightSteelBlue"
 | '''Genetic'''
-|bgcolor="Beige"|Type I [[Glycogen Storage Disease ]], Type 1 [[glycogen storage disease ]], SCHAD deficiency , [[Pyruvate dehydrogenase]] phosphatase deficiency , [[Pyruvate dehydrogenase]] deficiency, [[Pyruvate decarboxylase]] deficiency, [[Pyruvate carboxylase]] deficiency, Pyridoxine-5'-phosphate oxidase deficiency, Myopathy with deficiency of [[succinate dehydrogenase]] and aconitase, [[Mitochondrial]] genome inherited conditions, [[Mitochondrial]] encephalomyopathy -- aminoacidopathy , [[Mitochondrial ]]DNA depletion syndrome , [[Mitochondrial]] aspartyl-tRNA synthetase deficiency , Medium and long chan 3-hydroxyacyl-coenzyme A dehydrogenase deficiency , [[Malonyl-CoA]] decarboxylase deficiency, [[Malonyl-CoA]] decarboxylase deficiency , [[Malignant hyperpyrexia]], Hydroxyacyl-coa dehydrogenase type 2 deficiency , Holocarboxylase synthase deficiency , GRACILE syndrome ,[[Glycogenosis]] type 1b, [[Glycogenosis]] type 1a, [[Glycogen Storage Disease]] Type I , [[Glycogen storage disease]] type 1D , [[Glycogen storage disease]] type 1C , Fructose-1,6-bisphosphatase deficiency, , Fructose-1,6-diphosphatase deficiency, Fructose-1-phosphate aldolase deficiency, [[Fructose]] intolerance, [[Dihydrolipoamide dehydrogenase]] deficiency, Decreased activity of [[pyruvate dehydrogenase  ]], Decreased activity  [[pyruvate carboxylase ]], 3-methylglutaconic aciduria, type 4  , 3-Hydroxyisobutyric aciduria, 3-Hydroxyacyl-CoA Dehydrogenase II Deficiency , 17- beta-hydroxysteroid dehydrogenase X deficiency
+|bgcolor="Beige"| [[Fructose intolerance]],  [[fructose-1-phosphate aldolase deficiency]],  [[fructose-1,6-diphosphatase deficiency]],  [[glycogen storage disease]],  [[holocarboxylase synthase deficiency]], [[MELAS]],  [[MERRF]],  [[mitochondrial myopathy]],  [[pyruvate carboxylase deficiency]],  [[pyruvate dehydrogenase deficiency]],  [[von Gierke disease]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Hematologic'''
-|bgcolor="Beige"|[[Burkitt's lymphoma]]
+|bgcolor="Beige"| [[Anemia]], [[Burkitt's lymphoma]],  [[leukemia]],  [[non Hodgkin's lymphoma]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Iatrogenic'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Cardiac catheterization]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Infectious Disease'''
-|bgcolor="Beige"|[[Sepsis]] , [[Acquired immune deficiency syndrome  ]]
+|bgcolor="Beige"| [[Acquired immune deficiency syndrome]],  [[sepsis]]
 |-
 |-bgcolor="LightSteelBlue"
@@ Line 86: / Line 86: @@
 |-bgcolor="LightSteelBlue"
 | '''Neurologic'''
-|bgcolor="Beige"|Subacute necrotising encephalomyelopathy , [[Grand mal seizure ]] , [[Ethylmalonic encephalopathy]]
+|bgcolor="Beige"| [[Ethylmalonic encephalopathy]],  [[grand mal seizure]],  [[seizures]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Nutritional/Metabolic'''
-|bgcolor="Beige"|[[Von Gierke Disease ]] , [[Mitochondrial]] toxicity , [[Mitochondrial]] neurogastrointestinal encephalopathy syndrome  , [[Mitochondrial myopathy]] , Impaired [[pyruvate]] utilization , [[Coenzyme Q10]] deficiency
+|bgcolor="Beige"| [[Ariboflavinosis]],  [[beriberi heart disease]],  [[fructose intolerance]],  [[fructose-1-phosphate aldolase deficiency]],  [[fructose-1,6-diphosphatase deficiency]],  [[pyruvate carboxylase deficiency]],  [[pyruvate dehydrogenase deficiency]],  [[thiamine deficiency]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Obstetric/Gynecologic'''
-|bgcolor="Beige"|[[Fetal distress]]
+|bgcolor="Beige"| [[fetal distress]],  [[oligohydramnios]],
 |-
 |-bgcolor="LightSteelBlue"
 | '''Oncologic'''
-|bgcolor="Beige"|[[Non Hodgkin's lymphoma]] , [[Malignancy ]]
+|bgcolor="Beige"| [[burkitt's lymphoma]],  [[cancer]],  [[leukemia]],  [[non Hodgkin's lymphoma]],  [[pheochromocytoma]],
 |-
 |-bgcolor="LightSteelBlue"
@@ Line 114: / Line 114: @@
 |-bgcolor="LightSteelBlue"
 | '''Pulmonary'''
-|bgcolor="Beige"|Severe[[ hypoxemia]] (PO2 <25 to 30 mmHg) , Severe [[asthma ]] , [[Respiratory failure]] , Lung disease - reduced oxygen intake , [[Hypoxia]]
+|bgcolor="Beige"| [[Asthma]],  [[hypercapnia]],  [[hypoxia]],  [[pulmonary edema]],  [[respiratory failure]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Renal/Electrolyte'''
-|bgcolor="Beige"|Renal failure , [[Hemofiltration]]
+|bgcolor="Beige"| [[Diabetic nephropathy]],  [[hemofiltration]],  [[renal failure]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Rheumatology/Immunology/Allergy'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Latent autoimmune diabetes]]
 |-
 |-bgcolor="LightSteelBlue"
@@ Line 138: / Line 138: @@
 |-bgcolor="LightSteelBlue"
 | '''Miscellaneous'''
-|bgcolor="Beige"|Succinic [[acidemia ]] , [[Strychnine]] , Severe [[exercise ]] , [[Reye's syndrome]] , Reduced [[oxygen]] utilization , Multiple organ dysfunction  , Marked [[acidemia ]] , [[Intravenous pyelogram]] , [[Idiopathic]] , [[Hypothermic]] shivering  , [[Hypoperfusion]] , [[Haemorrhage]] , Finnish lethal neonatal metabolic syndrome  , Decreased [[oxygen]] delivery , Cuffed [[blood]] sample, [[Chronic fatigue syndrome]] , [[MERRF]] , [[MELAS]]
+|bgcolor="Beige"| [[Bacterial overgrowth|Bacterial overgrowth of small intestine]],  [[chronic fatigue syndrome]], [[coenzyme Q10|coenzyme q10 deficiency]],  [[exercise]],  [[glycogen storage disease]],  [[hypothermia]],  [[idiopathic]],  [[malignant hyperpyrexia]],  [[mitochondrial toxicity]],  [[smoke inhalation]]
 |-
 |}
+<font color="white">Causes by Organ System developed by WikiDoc.org, Copyleft 2013</font>
 ===Causes in Alphabetical Order===
 {{col-begin|width=80%}}