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| *[[Exercise]] | | *[[Exercise]] |
| *[[Fetal distress]] | | *[[Fetal distress]] |
| | *[[Fructose intolerance]] |
| {{col-break|width=33%}} | | {{col-break|width=33%}} |
| *[[Fructose intolerance]]
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| *[[Fructose-1-phosphate aldolase deficiency]] | | *[[Fructose-1-phosphate aldolase deficiency]] |
| *[[Fructose-1,6-diphosphatase deficiency]] | | *[[Fructose-1,6-diphosphatase deficiency]] |
| Line 210: |
Line 210: |
| *[[Mesenteric ischemia]] | | *[[Mesenteric ischemia]] |
| *[[Metabolic syndrome]] | | *[[Metabolic syndrome]] |
| {{col-break|width=33%}}
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| *[[Metformin]] | | *[[Metformin]] |
| *[[Mitochondrial myopathy]] | | *[[Mitochondrial myopathy]] |
| | {{col-break|width=33%}} |
| *[[Mitochondrial toxicity]] | | *[[Mitochondrial toxicity]] |
| *[[Multiple organ dysfunction syndrome]] | | *[[Multiple organ dysfunction syndrome]] |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Lactic acidosis is one of the most common causes of high anion gap metabolic acidosis and is usually associated with a serum lactate levels above 4 mmol/L. Reduced oxygen tension shunts glycolysis towards pyruvate production, which in turn leads to lactate accumulation since pyruvate can no longer undergo aerobic metabolism.
Causes
Life Threatening Causes
Common Causes
Causes by Organ System
| Cardiovascular
|
Cardiac arrest, cardiac catheterization, cardiomyopathy, heart failure, hemorrhage, hypoperfusion, hypovolemia, multiple organ dysfunction syndrome, myocardial infarction, shock, ST elevation myocardial infarction complications
|
| Chemical/Poisoning
|
Alcoholism, carbon monoxide poisoning, contrast medium, cyanide poisoning, ethanol, intravenous pyelogram, isopropyl alcohol
|
| Dental
|
No underlying causes
|
| Dermatologic
|
No underlying causes
|
| Drug Side Effect
|
Abacavir, adefovir, atenolol, biguanide, buformin, didanosine, emtricitabine, entecavir, lamivudine, linezolid, metformin, paracetamol, phenformin, Reye's syndrome, salicylate intoxication, stavudine, strychnine, telbivudine, tenofovir, zalcitabine
|
| Ear Nose Throat
|
No underlying causes
|
| Endocrine
|
Diabetic nephropathy, hypoglycemia, latent autoimmune diabetes, metabolic syndrome
|
| Environmental
|
No underlying causes
|
| Gastroenterologic
|
Acute liver failure, intestinal ischemia, liver failure, mesenteric ischemia, short bowel syndrome, small bowel bacterial overgrowth
|
| Genetic
|
Fructose intolerance, fructose-1-phosphate aldolase deficiency, fructose-1,6-diphosphatase deficiency, glycogen storage disease, holocarboxylase synthase deficiency, MELAS, MERRF, mitochondrial myopathy, pyruvate carboxylase deficiency, pyruvate dehydrogenase deficiency, von Gierke disease
|
| Hematologic
|
Anemia, Burkitt's lymphoma, leukemia, non Hodgkin's lymphoma
|
| Iatrogenic
|
Cardiac catheterization
|
| Infectious Disease
|
Acquired immune deficiency syndrome, sepsis, small bowel bacterial overgrowth
|
| Musculoskeletal/Orthopedic
|
No underlying causes
|
| Neurologic
|
Ethylmalonic encephalopathy, grand mal seizure, seizures
|
| Nutritional/Metabolic
|
Ariboflavinosis, beriberi heart disease, fructose intolerance, fructose-1-phosphate aldolase deficiency, fructose-1,6-diphosphatase deficiency, pyruvate carboxylase deficiency, pyruvate dehydrogenase deficiency, thiamine deficiency
|
| Obstetric/Gynecologic
|
Fetal distress, oligohydramnios,
|
| Oncologic
|
Burkitt's lymphoma, cancer, leukemia, non Hodgkin's lymphoma, pheochromocytoma,
|
| Ophthalmologic
|
No underlying causes
|
| Overdose/Toxicity
|
No underlying causes
|
| Psychiatric
|
No underlying causes
|
| Pulmonary
|
Asthma, hypercapnia, hypoxia, pulmonary edema, respiratory failure
|
| Renal/Electrolyte
|
Diabetic nephropathy, hemofiltration, renal failure
|
| Rheumatology/Immunology/Allergy
|
Latent autoimmune diabetes
|
| Sexual
|
No underlying causes
|
| Trauma
|
No underlying causes
|
| Urologic
|
No underlying causes
|
| Miscellaneous
|
Chronic fatigue syndrome , coenzyme q10 deficiency, exercise, glycogen storage disease, hypothermia, idiopathic, malignant hyperpyrexia, mitochondrial toxicity, smoke inhalation
|
Causes by Organ System developed by WikiDoc.org, Copyleft 2013
Causes in Alphabetical Order
References
Template:WikiDoc Sources