Abdominal aortic aneurysm causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Common causes of abdominal aortic aneurysm include atherosclerosis, hypertension and smoking.

Causes

Common Causes

• Atherosclerosis
• Hypertension
• Smoking

Causes by Organ System

Cardiovascular	Anastomosis, aortic dissection, arteritis, atheroma, atherosclerosis, bicuspid aortic valve, coarctation of the aorta, coronary artery disease, cystic medial necrosis, endocarditis, heart valve surgery, hypercholesterolemia, hypertension, peripheral vascular disease, vasculitis
Chemical / poisoning	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Chemotherapy
Ear Nose Throat	No underlying causes
Endocrine	Diabetes
Environmental	No underlying causes
Gastroenterologic	Alpha 1-antitrypsin deficiency, appendectomy, cholecystectomy, cholecystitis, cirrhosis, colorectal surgery, diverticulitis, esophageal varices, gastrointestinal endoscopy, gastrointestinal perforation, hemorrhoids, pancreatic pseudocyst
Genetic	Alpha 1-antitrypsin deficiency, arterial tortuosity syndrome, bicuspid aortic valve, chromosome 11q24, chromosome 19q13, chromosome 9p21, chromosomes 4q32-34, Ehlers-Danlos syndrome, familial, genetic polymorphisms of genes controlling angiotensin converting enzyme, methylene tetrahydrofolate reductase, and matrix metalloproteinase-9, HLA-DRB 1 alleles b1*0404, HLA-DRB1 alleles b1*15, Loeys-Dietz syndrome, long arm of chromosome 16, Marfan syndrome, pseudoxanthoma elasticum, Turner's syndrome, X-linked mutation
Hematologic	No underlying causes
Iatrogenic	Appendectomy, cholecystectomy, colorectal surgery, gastrointestinal endoscopy, heart valve surgery, hemodialysis, hip replacement surgery, nerve block, oral surgery, percutaneous access for cardiac catheterization, prior aortic repairs
Infectious Disease	Acinetobacter, arteritis, aspergillus, bacteremia, bacteroides, brucella, burkholderia pseudomallei, campylobacter , candida, clostridium, corynebacterium, coxiella burnetii, cryptococcus, escherichia coli, endocarditis, haemophilus influenzae, HIV , intravenous drug use, klebsiella, lactococcus cremoris, listeria, melioidosis, methicillin-resistant staphylococcus aureus, mycobacterium tuberculosis, mycosis, nonpneumococcal streptococcus, oral surgery, osteomyelitis, periodontal infection, pneumonia, pseudallescheria boydii, pseudomonas, rothia dentocariosa, salmonella, septic embolic, soft tissue infection, staphylococcus aureus, staphylococcus epidermidis, streptococcus pneumoniae, treponema pallidum, urinary tract infection, vancomycin intermediate s. aureus, V=vertebral osteomyelitis, yersinia
Musculoskeletal / Ortho	Arterial tortuosity syndrome, hip replacement surgery, osteomyelitis, vertebral osteomyelitis
Neurologic	Cerebrovascular disease
Nutritional / Metabolic	Lipid metabolism disorders
Obstetric/Gynecologic	No underlying causes
Oncologic	Malignancies
Opthalmologic	No underlying causes
Overdose / Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	Alpha 1-antitrypsin deficiency, Chronic obstructive pulmonary disease
Renal / Electrolyte	Hemodialysis, polycystic kidney disease
Rheum / Immune / Allergy	Arteritis, chronic glucocorticoid therapy, giant cell arteritis, immunodeficiency, post-transplant, relapsing polychondritis , Takayasu disease, temporal arteries
Sexual	No underlying causes
Trauma	Abdominal trauma, chest trauma, near drowning
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	Alcoholism, caucasian race, Ehlers-Danlos syndrome, male gender, old age, presence of other large aneurysms(iliac, femoral, popliteal, carotid), pseudoaneurysms, smoking

Causes in Alphabetical Order

• Abdominal trauma
• Acinetobacter
• Alcoholism
• Alpha 1-antitrypsin deficiency
• Anastomosis
• Aortic dissection
• Appendectomy
• Arterial tortuosity syndrome
• Arteritis
• Aspergillus
• Atheroma
• Atherosclerosis
• Bacteremia
• Bacteroides
• Bicuspid aortic valve
• Brucella
• Burkholderia pseudomallei
• Campylobacter
• Candida
• Caucasian race
• Cerebrovascular disease
• Chemotherapy
• Chest trauma
• Cholecystectomy
• Cholecystitis
• Chromosome 11q24
• Chromosome 19q13
• Chromosome 9p21
• Chromosomes 4q32-34
• Chronic glucocorticoid therapy
• Chronic obstructive pulmonary disease
• Cirrhosis
• Clostridium
• Coarctation of the aorta
• Colorectal surgery
• Coronary artery disease
• Corynebacterium
• Coxiella burnetii
• Cryptococcus

• Cystic medial necrosis
• Diabetes
• Diverticulitis
• Escherichia coli
• Ehlers-danlos syndrome
• Endocarditis
• Esophageal varices
• Familial
• Gastrointestinal endoscopy
• Gastrointestinal perforation
• Genetic polymorphisms of genes controlling angiotensin converting enzyme, methylene tetrahydrofolate reductase, and matrix metalloproteinase-9
• Giant cell arteritis
• Haemophilus influenzae
• Heart valve surgery
• Hemodialysis
• Hemorrhoids
• Hip replacement surgery
• HIV
• HLA-DRB1 alleles b1*0404
• HLA-DRB1 alleles b1*15
• Hypercholesterolemia
• Hypertension
• Immunodeficiency
• Intravenous drug use
• Klebsiella
• Lactococcus cremoris
• Lipid metabolism disorders
• Listeria
• Loeys-dietz syndrome
• Long arm of chromosome 16
• Male gender
• Malignancies
• Marfan syndrome
• Melioidosis
• Methicillin-resistant staphylococcus aureus
• Mycobacterium tuberculosis
• Mycosis

• Near drowning
• Nerve block
• Nonpneumococcal streptococcus
• Old age
• Oral surgery
• Osteomyelitis
• Pancreatic pseudocyst
• Percutaneous access for cardiac catheterization
• Periodontal infection
• Peripheral vascular disease
• Pneumonia
• Polycystic kidney disease
• Post-transplant
• Presence of other large aneurysms (iliac, femoral, popliteal, carotid)
• Prior aortic repairs
• Pseudallescheria boydii
• Pseudoaneurysms
• Pseudomonas
• Pseudoxanthoma elasticum
• Relapsing polychondritis
• Rothia dentocariosa
• Salmonella
• Septic embolic
• Smoking
• Soft tissue infection
• Staphylococcus aureus
• Staphylococcus epidermidis
• Streptococcus pneumoniae
• Takayasu disease
• Temporal arteries
• Treponema pallidum
• Turner's syndrome
• Urinary tract infection
• Vancomycin intermediate s. aureus
• Vasculitis
• Vertebral osteomyelitis
• X-linked mutation
• Yersinia