Minimal change disease medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
Normal 0 false false false EN-US JA X-NONE Pharmacologic therapy using corticosteroids is considered the mainstay of therapy for minimal change disease. According to the National Kidney Foundation (NKF) Kidney Disease – Improve Global Outcomes (KGIDO) guidelines in 2012,( 23871408) initial empirical treatment using corticosteroids in patients presenting with nephrotic syndrome prior to a kidney biopsy is recommended. Notably also, the use of statins for hyperlipidemia and ACE-I or ARB for proteinuria are both not recommended in patients presenting with the initial episode of MCD. | |||
==Medical Therapy== | ==Medical Therapy== | ||
[[Prednisone]] is prescribed along with a blood pressure medication, typically an [[ACE inhibitor]] such as [[lisinopril]]. Often the liver is overactive with minimal change disease and over produces [[cholesterol]]. Therefore a [[statin]] drug is often prescribed for the duration of the treatment. When the urine is clear of protein, the drugs can be discontinued. 50% of patients will relapse and need further treatment. | [[Prednisone]] is prescribed along with a blood pressure medication, typically an [[ACE inhibitor]] such as [[lisinopril]]. Often the liver is overactive with minimal change disease and over produces [[cholesterol]]. Therefore a [[statin]] drug is often prescribed for the duration of the treatment. When the urine is clear of protein, the drugs can be discontinued. 50% of patients will relapse and need further treatment. | ||
Revision as of 06:22, 25 November 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Normal 0 false false false EN-US JA X-NONE Pharmacologic therapy using corticosteroids is considered the mainstay of therapy for minimal change disease. According to the National Kidney Foundation (NKF) Kidney Disease – Improve Global Outcomes (KGIDO) guidelines in 2012,( 23871408) initial empirical treatment using corticosteroids in patients presenting with nephrotic syndrome prior to a kidney biopsy is recommended. Notably also, the use of statins for hyperlipidemia and ACE-I or ARB for proteinuria are both not recommended in patients presenting with the initial episode of MCD.
Medical Therapy
Prednisone is prescribed along with a blood pressure medication, typically an ACE inhibitor such as lisinopril. Often the liver is overactive with minimal change disease and over produces cholesterol. Therefore a statin drug is often prescribed for the duration of the treatment. When the urine is clear of protein, the drugs can be discontinued. 50% of patients will relapse and need further treatment.