Focal segmental glomerulosclerosis epidemiology and demographics: Difference between revisions
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==Epidemiology & Demographics== | ==Epidemiology & Demographics== | ||
Focal segmental glomerulosclerosis (FSGS) is considered the most common cause of nephrotic syndrome worldwide and the most common primary renal cause of end-stage renal disease (ESRD) in whites and blacks, contributing to approximately 2% of ESRD.<ref name="pmid15492947">{{cite journal| author=Kitiyakara C, Eggers P, Kopp JB| title=Twenty-one-year trend in ESRD due to focal segmental glomerulosclerosis in the United States. | journal=Am J Kidney Dis | year= 2004 | volume= 44 | issue= 5 | pages= 815-25 | pmid=15492947 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15492947 }} </ref> | Focal segmental glomerulosclerosis (FSGS) is considered the most common cause of nephrotic syndrome worldwide and the most common primary renal cause of end-stage renal disease (ESRD) in whites and blacks, contributing to approximately 2% of ESRD.<ref name="pmid15492947">{{cite journal| author=Kitiyakara C, Eggers P, Kopp JB| title=Twenty-one-year trend in ESRD due to focal segmental glomerulosclerosis in the United States. | journal=Am J Kidney Dis | year= 2004 | volume= 44 | issue= 5 | pages= 815-25 | pmid=15492947 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15492947 }} </ref> | ||
FSGS is more common in blacks. It accounts for approximately 35% of nephrotic syndromes in all cases and approximately 50% of nephrotic syndrome in blacks.<ref name="pmid17151873">{{cite journal| author=Hogg R, Middleton J, Vehaskari VM| title=Focal segmental glomerulosclerosis--epidemiology aspects in children and adults. | journal=Pediatr Nephrol | year= 2007 | volume= 22 | issue= 2 | pages= 183-6 | pmid=17151873 | doi=10.1007/s00467-006-0370-5 | pmc=PMC1764601 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17151873 }} </ref> The disease is considered a disease of the adult population (vs. minimal change disease which is much more common among children). In a 21-year follow-up study that excludes HIV-associated nephropathy, the median age of FSGS ESRD is 40-49 years in black adults and 70-79 in white and Asian adults.<ref name="pmid15492947">{{cite journal| author=Kitiyakara C, Eggers P, Kopp JB| title=Twenty-one-year trend in ESRD due to focal segmental glomerulosclerosis in the United States. | journal=Am J Kidney Dis | year= 2004 | volume= 44 | issue= 5 | pages= 815-25 | pmid=15492947 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15492947 }} </ref> The male to female ratio is 1.5-2 to 1.<ref name="pmid15492947">{{cite journal| author=Kitiyakara C, Eggers P, Kopp JB| title=Twenty-one-year trend in ESRD due to focal segmental glomerulosclerosis in the United States. | journal=Am J Kidney Dis | year= 2004 | volume= 44 | issue= 5 | pages= 815-25 | pmid=15492947 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15492947 }} </ref> | FSGS is more common in blacks. It accounts for approximately 35% of nephrotic syndromes in all cases and approximately 50% of nephrotic syndrome in blacks.<ref name="pmid17151873">{{cite journal| author=Hogg R, Middleton J, Vehaskari VM| title=Focal segmental glomerulosclerosis--epidemiology aspects in children and adults. | journal=Pediatr Nephrol | year= 2007 | volume= 22 | issue= 2 | pages= 183-6 | pmid=17151873 | doi=10.1007/s00467-006-0370-5 | pmc=PMC1764601 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17151873 }} </ref> The disease is considered a disease of the adult population (vs. minimal change disease which is much more common among children). In a 21-year follow-up study that excludes HIV-associated nephropathy, the median age of FSGS ESRD is 40-49 years in black adults and 70-79 in white and Asian adults.<ref name="pmid15492947">{{cite journal| author=Kitiyakara C, Eggers P, Kopp JB| title=Twenty-one-year trend in ESRD due to focal segmental glomerulosclerosis in the United States. | journal=Am J Kidney Dis | year= 2004 | volume= 44 | issue= 5 | pages= 815-25 | pmid=15492947 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15492947 }} </ref> The male to female ratio is 1.5-2 to 1.<ref name="pmid15492947">{{cite journal| author=Kitiyakara C, Eggers P, Kopp JB| title=Twenty-one-year trend in ESRD due to focal segmental glomerulosclerosis in the United States. | journal=Am J Kidney Dis | year= 2004 | volume= 44 | issue= 5 | pages= 815-25 | pmid=15492947 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15492947 }} </ref> | ||
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Epidemiology & Demographics
Focal segmental glomerulosclerosis (FSGS) is considered the most common cause of nephrotic syndrome worldwide and the most common primary renal cause of end-stage renal disease (ESRD) in whites and blacks, contributing to approximately 2% of ESRD.[1]
FSGS is more common in blacks. It accounts for approximately 35% of nephrotic syndromes in all cases and approximately 50% of nephrotic syndrome in blacks.[2] The disease is considered a disease of the adult population (vs. minimal change disease which is much more common among children). In a 21-year follow-up study that excludes HIV-associated nephropathy, the median age of FSGS ESRD is 40-49 years in black adults and 70-79 in white and Asian adults.[1] The male to female ratio is 1.5-2 to 1.[1]
References
- ↑ 1.0 1.1 1.2 Kitiyakara C, Eggers P, Kopp JB (2004). "Twenty-one-year trend in ESRD due to focal segmental glomerulosclerosis in the United States". Am J Kidney Dis. 44 (5): 815–25. PMID 15492947.
- ↑ Hogg R, Middleton J, Vehaskari VM (2007). "Focal segmental glomerulosclerosis--epidemiology aspects in children and adults". Pediatr Nephrol. 22 (2): 183–6. doi:10.1007/s00467-006-0370-5. PMC 1764601. PMID 17151873.