Cefamandole adverse reactions: Difference between revisions

Latest revision as of 00:11, 6 January 2014

Cefamandole
MANDOL^® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Overdosage
Dosage and Administration
How Supplied

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Adverse Reactions

Gastrointestinal

Symptoms of pseudomembranous colitis may appear either during or after antibiotic treatment. Nausea and vomiting have been reported rarely. As with some penicillins and some other cephalosporins, transient hepatitis and cholestatic jaundice have been reported rarely.

Hypersensitivity

Anaphylaxis, maculopapular rash, urticaria, eosinophilia, and drug fever have been reported. These reactions are more likely to occur in patients with a history of allergy, particularly to penicillin.

Blood

Thrombocytopenia has been reported rarely. Neutropenia has been reported, especially in long courses of treatment. Some individuals have developed positive direct Coombs' tests during treatment with the cephalosporin antibiotics.

Liver

Transient rise in SGOT, SGPT, and alkaline phosphatase levels has been noted.

Kidney

Decreased creatinine clearance has been reported in patients with prior renal impairment. As with some other cephalosporins, transitory elevations of BUN have occasionally been observed with Mandol (cefamandole) ; their frequency increases in patients over 50 years of age. In some of these cases, there was also a mild increase in serum creatinine.

Local Reactions

Pain on intramuscular injection is infrequent. Thrombophlebitis occurs rarely.^[1]

References

↑ "http://www.rxlist.com/mandol-drug.htm". External link in |title= (help)

Adapted from the FDA Package Insert.

[www.rxlist.com-1] "http://www.rxlist.com/mandol-drug.htm". External link in |title= (help)

[1]

@@ Line 4: / Line 4: @@
 ==Adverse Reactions==
-Gastrointestinal  Symptoms of pseudomembranous colitis may appear either during or after antibiotic treatment. Nausea and vomiting have been reported rarely. As with some penicillins and some other cephalosporins, transient hepatitis and cholestatic jaundice have been reported rarely.
-Hypersensitivity  Anaphylaxis, maculopapular rash, urticaria, eosinophilia, and drug fever have been reported. These reactions are more likely to occur in patients with a history of allergy, particularly to penicillin.
+====Gastrointestinal====
-Blood  Thrombocytopenia has been reported rarely. Neutropenia has been reported, especially in long courses of treatment. Some individuals have developed positive direct Coombs' tests during treatment with the cephalosporin antibiotics.
-Liver  Transient rise in SGOT, SGPT, and alkaline phosphatase levels has been noted.
+Symptoms of pseudomembranous colitis may appear either during or after antibiotic treatment. Nausea and vomiting have been reported rarely. As with some penicillins and some other cephalosporins, transient hepatitis and cholestatic jaundice have been reported rarely.
-Kidney  Decreased creatinine clearance has been reported in patients with prior renal impairment. As with some other cephalosporins, transitory elevations of BUN have occasionally been observed with Mandol (cefamandole) ; their frequency increases in patients over 50 years of age. In some of these cases, there was also a mild increase in serum creatinine.
+====Hypersensitivity====
-Local Reactions  Pain on intramuscular injection is infrequent. Thrombophlebitis occurs rarely.<ref name="www.rxlist.com">{{Cite web  | last =  | first =  | title = http://www.rxlist.com/mandol-drug.htm | url = http://www.rxlist.com/mandol-drug.htm | publisher =  | date =  |accessdate = }}</ref>
+Anaphylaxis, maculopapular rash, urticaria, eosinophilia, and drug fever have been reported. These reactions are more likely to occur in patients with a history of allergy, particularly to penicillin.
+====Blood====
+Thrombocytopenia has been reported rarely. Neutropenia has been reported, especially in long courses of treatment. Some individuals have developed positive direct Coombs' tests during treatment with the cephalosporin antibiotics.
+====Liver====
+Transient rise in SGOT, SGPT, and alkaline phosphatase levels has been noted.
+====Kidney====
+Decreased creatinine clearance has been reported in patients with prior renal impairment. As with some other cephalosporins, transitory elevations of BUN have occasionally been observed with Mandol (cefamandole) ; their frequency increases in patients over 50 years of age. In some of these cases, there was also a mild increase in serum creatinine.
+====Local Reactions====
+Pain on intramuscular injection is infrequent. Thrombophlebitis occurs rarely.<ref name="www.rxlist.com">{{Cite web  | last =  | first =  | title = http://www.rxlist.com/mandol-drug.htm | url = http://www.rxlist.com/mandol-drug.htm | publisher =  | date =  |accessdate = }}</ref>
 ==References==