Disseminated intravascular coagulation causes: Difference between revisions

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Revision as of 16:09, 14 February 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ogheneochuko Ajari, MB.BS, MS [2]

Overview

There are a variety of causes of DIC^[1], all usually causing the release of chemicals into the blood that instigates the coagulation.

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Disseminated intravascular coagulation in itself is a life-threatening condition and must be treated as such irrespective of the cause.

Common Causes

Causes by Organ System

Cardiovascular	Aortic aneurysm, malignant hypertension, myocardial infarction, septic shock, shock, vasculitis
Chemical / poisoning	Snake bite (Elapid)
Dermatologic	Purpura fulminans, Raynaud's disease, rheumatoid arthritis, vasculitis
Drug Side Effect	Amphetamine, cocaine, interleukin 2, serotonin syndrome
Ear Nose Throat	No underlying causes
Endocrine	No underlying causes
Environmental	No underlying causes
Gastroenterologic	Acute fatty liver of pregnancy, acute hepatic failure, acute pancreatitis, Crohn disease, fulminant hepatic failure, liver disease, ulcerative colitis
Genetic	No underlying causes
Hematologic	Acute hemolytic transfusion reactions, acute myeloid leukemia, acute promyelocytic leukemia, antiphospholipid syndrome, Kasabach-Merritt syndrome, myeloproliferative syndrome, paroxysmal nocturnal hemoglobinuria, purpura fulminans, Trousseau's syndrome
Iatrogenic	Acute renal allograft rejection, Denver shunt, extensive surgery, LeVeen shunt, liver transplantation, peritoneovenous shunt, prosthetic devices, serotonin syndrome, surgery, recent anesthesia, ventricular assist devices
Infectious Disease	Arenaviruses, Argentine hemorrhagic fever, aspergillosis, Bolivian hemorrhagic fever, capnocytophaga canimorsus, CMV, HELLP syndrome, hepatitis viruses, histoplasmosis, malaria (malignant tertian), meningococcal septicaemia, mycoplasma pneumoniae, neisseria meningiditis, osteomyelitis, rocky mountain spotted fever, sarcoidosis, sepsis, septic shock, sleeping sickness (East African), streptococcus pneumoniae, tuberculosis, typhoid fever, viral hemorrhagic fevers, VZV
Musculoskeletal / Ortho	No underlying causes
Neurologic	No underlying causes
Nutritional / Metabolic	No underlying causes
Obstetric/Gynecologic	Amniotic fluid embolism, Eclampsia, HELLP syndrome, Intrauterine death, Placental abruption, Pre-eclampsia, Retained intrauterine fetal demise
Oncologic	Acute myeloid leukemia, Acute promyelocytic leukemia, Cancers of lung, pancreas, prostate and stomach, Giant hemangioma, Kasabach-Merritt syndrome, Mucin-secreting adenocarcinoma, Myeloproliferative syndromes, Paraneoplastic syndrome, Trousseau's syndrome
Opthalmologic	No underlying causes
Overdose / Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	Empyema
Renal / Electrolyte	No underlying causes
Rheum / Immune / Allergy	Antiphospholipid syndrome, Macrophage activation syndrome, Raynaud disease, Rheumatoid arthritis
Sexual	No underlying causes
Trauma	Burns, Crush syndrome, Head injury, Lightning strike, Motor vehicle accidents, Severe tissue injury
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	Heat stroke

Causes in Alphabetical Order

References

↑ Ledingham, J (2000). Concise Oxford Textbook of Medicine. Oxford University Press. ISBN 0-19-262870-4, Check |isbn= value: invalid character (help). Unknown parameter |coauthors= ignored (help)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Lurie S, Feinstein M, Mamet Y (2000). "Disseminated intravascular coagulopathy in pregnancy: thorough comprehension of etiology and management reduces obstetricians' stress". Arch Gynecol Obstet. 263 (3): 126–30. PMID 10763841.

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[1] Ledingham, J (2000). Concise Oxford Textbook of Medicine. Oxford University Press. ISBN 0-19-262870-4, Check |isbn= value: invalid character (help). Unknown parameter |coauthors= ignored (help)

[pmid10763841-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Lurie S, Feinstein M, Mamet Y (2000). "Disseminated intravascular coagulopathy in pregnancy: thorough comprehension of etiology and management reduces obstetricians' stress". Arch Gynecol Obstet. 263 (3): 126–30. PMID 10763841.

[1]

[2]

@@ Line 76: / Line 76: @@
 |-bgcolor="LightSteelBlue"
 | '''Iatrogenic'''
-|bgcolor="Beige"| [[Acute renal allograft rejection]], [[Denver shunt]], [[surgery|extensive surgery]], [[LeVeen shunt]], [[liver transplantation]],  [[peritoneovenous shunt]], [[prosthetic devices]], [[serotonin syndrome]], [[surgery]], [[anesthesia|recent anesthesia]], [[ventricular assist devices]]
+|bgcolor="Beige"| [[transplant rejection|Acute renal allograft rejection]], [[Denver shunt]], [[surgery|extensive surgery]], [[LeVeen shunt]], [[liver transplantation]],  [[peritoneovenous shunt]], [[prosthetic devices]], [[serotonin syndrome]], [[surgery]], [[anesthesia|recent anesthesia]], [[ventricular assist devices]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Infectious Disease'''
-|bgcolor="Beige"| [[Argentine hemorrhagic fever]], [[Aspergillosis]], [[Bolivian Hemorrhagic Fever]], [[Capnocytophaga canimorsus]], [[CMV]], [[Hepatitis viruses]], [[Histoplasmosis]], [[Malaria (malignant tertian)]], [[Meningococcal septicaemia]], [[Mycoplasma pneumoniae]], [[Neisseria meningiditis]], [[Neisseria meningitidis]], [[Osteomyelitis]], [[Rocky mountain spotted fever]], [[Sarcoidosis]], [[Septic shock]], [[Sleeping sickness (East African)]], [[Streptococcus pneumoniae]], [[Tuberculosis]], [[Typhoid fever]], [[Viral hemorrhagic fevers]], [[VZV]]
+|bgcolor="Beige"| [[arenavirus|Arenaviruses]], [[Argentine hemorrhagic fever]], [[aspergillosis]], [[hemorrhagic fever|Bolivian hemorrhagic fever]], [[capnocytophaga canimorsus]], [[CMV]], [[HELLP syndrome]], [[hepatitis|hepatitis viruses]], [[histoplasmosis]], [[malaria|malaria (malignant tertian)]], [[meningococcemia|meningococcal septicaemia]], [[mycoplasma pneumoniae]], [[neisseria meningiditis]], [[osteomyelitis]], [[rocky mountain spotted fever]], [[sarcoidosis]], [[sepsis]], [[septic shock]], [[African trypanosomiasis|sleeping sickness (East African)]], [[streptococcus pneumoniae]], [[tuberculosis]], [[typhoid fever]], [[hemorrhagic fever|viral hemorrhagic fevers]], [[VZV]]
 |-
 |-bgcolor="LightSteelBlue"