Creutzfeldt-Jakob disease laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
The diagnosis of CJD is suspected when there are typical clinical symptoms and signs such as rapidly progressing [[dementia]] with [[myoclonus]]. Analysis of CSF for [[14-3-3 protein]] is done to establish diagnosis. | The diagnosis of CJD is suspected when there are typical clinical symptoms and signs such as rapidly progressing [[dementia]] with [[myoclonus]]. Analysis of CSF for [[14-3-3 protein]] is done to establish probable diagnosis. Positive 14-3-3 protein in CSF analysis makes the diagnosis of CJD probable but it is not diagnostic of CJD.<ref name="Muayqil-2012">{{Cite journal | last1 = Muayqil | first1 = T. | last2 = Gronseth | first2 = G. | last3 = Camicioli | first3 = R. | title = Evidence-based guideline: diagnostic accuracy of CSF 14-3-3 protein in sporadic Creutzfeldt-Jakob disease: report of the guideline development subcommittee of the American Academy of Neurology. | journal = Neurology | volume = 79 | issue = 14 | pages = 1499-506 | month = Oct | year = 2012 | doi = 10.1212/WNL.0b013e31826d5fc3 | PMID = 22993290 }}</ref> | ||
==References== | ==References== | ||
Revision as of 02:52, 17 February 2014
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Overview
The diagnosis of CJD is suspected when there are typical clinical symptoms and signs such as rapidly progressing dementia with myoclonus. Analysis of CSF for 14-3-3 protein is done to establish probable diagnosis. Positive 14-3-3 protein in CSF analysis makes the diagnosis of CJD probable but it is not diagnostic of CJD.[1]
References
- ↑ Muayqil, T.; Gronseth, G.; Camicioli, R. (2012). "Evidence-based guideline: diagnostic accuracy of CSF 14-3-3 protein in sporadic Creutzfeldt-Jakob disease: report of the guideline development subcommittee of the American Academy of Neurology". Neurology. 79 (14): 1499–506. doi:10.1212/WNL.0b013e31826d5fc3. PMID 22993290. Unknown parameter
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