Creutzfeldt-Jakob disease other diagnostic studies: Difference between revisions
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{{Creutzfeldt-Jakob disease}} | {{Creutzfeldt-Jakob disease}} | ||
{{CMG}} | {{CMG}} | ||
==Overview== | |||
[[EEG]] findings of triphasic spikes have been included by CDC in the diagnostic criteria for probable Creutzfeldt-Jakob disease.<ref name="www.cdc.gov">{{Cite web | last = | first = | title = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | url = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | publisher = | date = | accessdate = 17 February 2014 }}</ref> | |||
==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
===Electroencephalography=== | ===Electroencephalography=== | ||
[[EEG]] findings are not diagnostic of CJD but they are supportive of a probable diagnosis of CJD. Periodic synchronus discharges (PSDs) occur either brfore or in synchronicity with [[myoclonus]].<ref name="Hayashi-1992">{{Cite journal | last1 = Hayashi | first1 = R. | last2 = Hanyu | first2 = N. | last3 = Kuwabara | first3 = T. | last4 = Moriyama | first4 = S. | title = Serial computed tomographic and electroencephalographic studies in Creutzfeldt-Jakob disease. | journal = Acta Neurol Scand | volume = 85 | issue = 3 | pages = 161-5 | month = Mar | year = 1992 | doi = | PMID = 1574996 }}</ref> | |||
Typical EEG findings in CJd include: | |||
* Periodic bi or triphasic sharp wave complexes (PSWCs) | |||
PSWCs can differentiate sporadic CJD from other types of CJD and other prion diseases. They are not present in variant CJD and only rarely present in familial CJD. They are absent in [[Kuru]], [[Gerstmann-Sträussler-Scheinker syndrome]] and [[fatal familial insomnia]].<ref name="Steinhoff-2004">{{Cite journal | last1 = Steinhoff | first1 = BJ. | last2 = Zerr | first2 = I. | last3 = Glatting | first3 = M. | last4 = Schulz-Schaeffer | first4 = W. | last5 = Poser | first5 = S. | last6 = Kretzschmar | first6 = HA. | title = Diagnostic value of periodic complexes in Creutzfeldt-Jakob disease. | journal = Ann Neurol | volume = 56 | issue = 5 | pages = 702-8 | month = Nov | year = 2004 | doi = 10.1002/ana.20261 | PMID = 15449324 }}</ref> | |||
===Biopsy=== | ===Biopsy=== | ||
In one third of patients with sporadic CJD, deposits of [[prion]] protein (scrapie), [[PrpSc|PrP<SUP>Sc</SUP>]], can be found in the [[skeletal muscle]] and/or the [[spleen]]. Diagnosis of [[vCJD]] can be supported by biopsy of the [[tonsils]], which harbour significant amounts of PrpSc; however, [[biopsy]] of [[brain]] tissue is the definitive diagnostic test. | In one third of patients with sporadic CJD, deposits of [[prion]] protein (scrapie), [[PrpSc|PrP<SUP>Sc</SUP>]], can be found in the [[skeletal muscle]] and/or the [[spleen]]. Diagnosis of [[vCJD]] can be supported by biopsy of the [[tonsils]], which harbour significant amounts of PrpSc; however, [[biopsy]] of [[brain]] tissue is the definitive diagnostic test. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
EEG findings of triphasic spikes have been included by CDC in the diagnostic criteria for probable Creutzfeldt-Jakob disease.[1]
Other Diagnostic Studies
Electroencephalography
EEG findings are not diagnostic of CJD but they are supportive of a probable diagnosis of CJD. Periodic synchronus discharges (PSDs) occur either brfore or in synchronicity with myoclonus.[2] Typical EEG findings in CJd include:
- Periodic bi or triphasic sharp wave complexes (PSWCs)
PSWCs can differentiate sporadic CJD from other types of CJD and other prion diseases. They are not present in variant CJD and only rarely present in familial CJD. They are absent in Kuru, Gerstmann-Sträussler-Scheinker syndrome and fatal familial insomnia.[3]
Biopsy
In one third of patients with sporadic CJD, deposits of prion protein (scrapie), PrPSc, can be found in the skeletal muscle and/or the spleen. Diagnosis of vCJD can be supported by biopsy of the tonsils, which harbour significant amounts of PrpSc; however, biopsy of brain tissue is the definitive diagnostic test.
References
- ↑ "http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html". Retrieved 17 February 2014. External link in
|title=(help) - ↑ Hayashi, R.; Hanyu, N.; Kuwabara, T.; Moriyama, S. (1992). "Serial computed tomographic and electroencephalographic studies in Creutzfeldt-Jakob disease". Acta Neurol Scand. 85 (3): 161–5. PMID 1574996. Unknown parameter
|month=ignored (help) - ↑ Steinhoff, BJ.; Zerr, I.; Glatting, M.; Schulz-Schaeffer, W.; Poser, S.; Kretzschmar, HA. (2004). "Diagnostic value of periodic complexes in Creutzfeldt-Jakob disease". Ann Neurol. 56 (5): 702–8. doi:10.1002/ana.20261. PMID 15449324. Unknown parameter
|month=ignored (help)