Chorioamnionitis medical therapy

Chorioamnionitis Microchapters
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Antimicrobial Therapy

Chorioamnionitis/Septic Abortion Treatment Preferred Regimen ▸ Cefoxitin 2 gm IV q6–8h OR ▸ Ticarcillin-Clavulanate 3.1 gm IV q4–6h OR ▸ DoripenemNAI 500 mg IV q8h OR ▸ Imipenem 0.5 gm IV q6h OR ▸ Meropenem 1 gm IV q8h OR ▸ Ampicillin-Sulbactam 3 gm IV q6h OR ▸ Ertapenem 1 gm IV q24h' OR ▸ Pipracillin-Tazobactam 4.5 gm IV q6h (or 4-hr infusion of 3.375 gm q8h) PLUS ▸ Doxycycline 100 mg IV/po q12h OR ▸ Clindamycin 450–900 mg IV q8h PLUS ▸ Ceftriaxone 2 gm IV q24h OR ▸ Gentamicin MDD: 2 mg per kg load, then 1.7 mg per kg q8h or OD: 5.1 (7 if critically ill) mg per kg q24h

• Cesarean section is reserved only for obstetrics indications, and antimicrobial coverage for anaerobes is required for such cases.

Antipyretic Therapy

Acetaminophen use for febrile patients with chorioamnionitis has shown remarkable improvement in fetal vitals and acid-base balance, with no increased risk for complications.