Argatroban

Argatroban

Clinical data
Routes of administration	intravenous
ATC code	B01AE03 (WHO)
Pharmacokinetic data
Bioavailability	100% (intravenous)
Protein binding	54%
Metabolism	hepatic
Elimination half-life	39 and 51 minutes
Identifiers
IUPAC name (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2- [[(3R)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl] sulfonylamino]pentanoyl]-4-methyl-piperidine-2- carboxylic acid
CAS Number	74863-84-6
PubChem CID	152951
DrugBank	APRD00105
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C23H36N6O5S
Molar mass	508.635 g/mol

WikiDoc Resources for Argatroban
Articles
Most recent articles on Argatroban Most cited articles on Argatroban Review articles on Argatroban Articles on Argatroban in N Eng J Med, Lancet, BMJ
Media
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Evidence Based Medicine
Cochrane Collaboration on Argatroban Bandolier on Argatroban TRIP on Argatroban
Clinical Trials
Ongoing Trials on Argatroban at Clinical Trials.gov Trial results on Argatroban Clinical Trials on Argatroban at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Argatroban NICE Guidance on Argatroban NHS PRODIGY Guidance FDA on Argatroban CDC on Argatroban
Books
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Commentary
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Definitions
Definitions of Argatroban
Patient Resources / Community
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Healthcare Provider Resources
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Continuing Medical Education (CME)
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International
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Business
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Experimental / Informatics
List of terms related to Argatroban

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Jesus Rosario Hernandez, M.D. [2]

Argatroban is an anticoagulant that is a small molecule direct thrombin inhibitor. In 2000, argatroban was licensed by the Food and Drug Administration (FDA) for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia. In 2002, it was approved for use during percutaneous coronary interventions in patients who have or at risk for developing HIT.

Argatroban is given intravenously. Argatroban is metabolized in the liver and has a half life of about 50 minutes. It is monitored by PTT. Because of its hepatic metabolism, it may be used in patients with renal dysfunction. (This is in contrast to lepirudin, a direct thrombin inhibitor that is primarily renally cleared).

It is manufactured by GlaxoSmithKline.

Category

ADP receptor inhibitors;Triazolopyrimidines;Organofluorides;Alcohols;AstraZeneca

FDA Package Insert

BRILINTA (ticagrelor) tablet

Indications and Usage | Dosage and Administration | Dosage Forms and Strengths | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Use in Specific Populations | Overdosage | Description | Clinical Pharmacology | Nonclinical Toxicology | Clinical Studies | How Supplied/Storage and Handling | Patient Counseling Information | Labels and Packages

Reference

• Di Nisio M, Middeldorp S, Buller HR. Direct thrombin inhibitors. N Engl J Med 2005;353:1028-40. PMID 16148288.

External links

• GlaxoSmithKline's website on argatroban