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==Overview==
==Overview==


Renal artery stenosis is most commonly caused by development of atherosclerotic plaque in the renal arteries (termed atherosclerotic renal artery stenosis). Less frequently, it is caused by fibromuscular dysplasia.
Renal artery stenosis is most commonly caused by development of atherosclerotic [[plaque]] in the renal arteries (termed atherosclerotic renal artery stenosis). Less frequently, it is caused by [[fibromuscular dysplasia]].


==Causes==
==Causes==


Renal artery stenosis (or renovascular hypertension) commonly results from atherosclerosis or fibromuscular dysplasia.  
Renal artery stenosis commonly results from atherosclerosis or [[fibromuscular dysplasia]].  


===Atherosclerotic Renal Artery Stenosis===
===Atherosclerotic Renal Artery Stenosis===


In atherosclerotic RAS, patients typically presnet with a progressive worsening of preexisting hypertension, often with a modest increase in serum creatinine. It is featured by accelerated rise in systolic blood pressure, accompanying target-organ damage, and decline of renal function during antihypertensive therapy. ARAS is sometimes heralded by crescendo angina, resistant congestive heart failure, or flash pulmonary edema.
In atherosclerotic RAS, patients typically present with a progressive worsening of preexisting hypertension, often with a modest increase in serum [[creatinine]]. It is featured by accelerated rise in [[systolic blood pressure]], accompanying target-organ damage, and decline of renal function during antihypertensive therapy. ARAS is sometimes heralded by crescendo [[angina]], resistant [[congestive heart failure]], or flash [[pulmonary edema]].


===Fibromuscular Dysplasia===
===Fibromuscular Dysplasia===


Fibromuscular dysplasia commonly affects midportions of the renal artery in younger individuals and rarely leads to major loss of renal function, although some progression may be seen, particularly in smokers. FMD lesions appear most often as hypertension of early onset and unusual severity. Occasionally, it presents as hypertension during pregnancy.
[[Fibromuscular dysplasia]] commonly affects mid-portions of the [[renal artery]] in younger individuals and rarely leads to major loss of renal function, although some progression may be seen, particularly in smokers. [[Fibromuscular dysplasia]] lesions appear most often as hypertension of early onset and unusual severity. Occasionally, it presents as [[hypertension]] during [[pregnancy]].


==References==
==References==

Revision as of 01:14, 15 May 2014

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Renal artery stenosis is most commonly caused by development of atherosclerotic plaque in the renal arteries (termed atherosclerotic renal artery stenosis). Less frequently, it is caused by fibromuscular dysplasia.

Causes

Renal artery stenosis commonly results from atherosclerosis or fibromuscular dysplasia.

Atherosclerotic Renal Artery Stenosis

In atherosclerotic RAS, patients typically present with a progressive worsening of preexisting hypertension, often with a modest increase in serum creatinine. It is featured by accelerated rise in systolic blood pressure, accompanying target-organ damage, and decline of renal function during antihypertensive therapy. ARAS is sometimes heralded by crescendo angina, resistant congestive heart failure, or flash pulmonary edema.

Fibromuscular Dysplasia

Fibromuscular dysplasia commonly affects mid-portions of the renal artery in younger individuals and rarely leads to major loss of renal function, although some progression may be seen, particularly in smokers. Fibromuscular dysplasia lesions appear most often as hypertension of early onset and unusual severity. Occasionally, it presents as hypertension during pregnancy.

References

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