Renal artery stenosis risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shivam Singla, M.D.[2] Yazan Daaboul, Serge Korjian

Overview

Cardiovascular risk factors are considered the most important risk factors for the development of Renal artery stenosis. The Most important risk factors are advanced age, smoking, hypertension, dyslipidemia, diabetes, and known vascular disease.

Risk Factors

In both men and females, RAS may develop. It is more common in elderly persons. Cardiovascular risk factors are the most important risk factors for the initiation and progression of atherosclerotic renal artery disease (ARAS). The most common risk factors associated with renal artery stenosis are[1][2][3]:

- Diet having a high content of cholesterol, carbohydrates, and sodium

- Hypertension

- Diabetes

- Peripheral vascular disease

- Coronary artery disease

- Family history of cardiovascular disease

- Diet rich in cholesterol

- Sedentary lifestyle

- Obesity

- Smoking

It is now clear that the prevalence of ARAS is higher among patients with hypertension, and among those who had prior cardiac catheterization procedures or with known coronary artery disease. The prevalence of ARAS in these patients increases drastically to reach up to 30-50% of all patients.[2][4][5][6]

References

  1. Zoccali C, Mallamaci F, Finocchiaro P (2002). "Atherosclerotic renal artery stenosis: epidemiology, cardiovascular outcomes, and clinical prediction rules". J Am Soc Nephrol. 13 Suppl 3: S179–83. PMID 12466310.
  2. 2.0 2.1 Harding MB, Smith LR, Himmelstein SI, Harrison K, Phillips HR, Schwab SJ; et al. (1992). "Renal artery stenosis: prevalence and associated risk factors in patients undergoing routine cardiac catheterization". J Am Soc Nephrol. 2 (11): 1608–16. PMID 1610982.
  3. MacDowall P, Kalra PA, O'Donoghue DJ, Waldek S, Mamtora H, Brown K (1998). "Risk of morbidity from renovascular disease in elderly patients with congestive cardiac failure". Lancet. 352 (9121): 13–6. PMID 9800739.
  4. Buller CE, Nogareda JG, Ramanathan K, Ricci DR, Djurdjev O, Tinckam KJ; et al. (2004). "The profile of cardiac patients with renal artery stenosis". J Am Coll Cardiol. 43 (9): 1606–13. doi:10.1016/j.jacc.2003.11.050. PMID 15120819.
  5. Miralles M, Corominas A, Cotillas J, Castro F, Clara A, Vidal-Barraquer F (1998). "Screening for carotid and renal artery stenoses in patients with aortoiliac disease". Ann Vasc Surg. 12 (1): 17–22. PMID 9451991.
  6. Swartbol P, Pärsson H, Thorvinger B, Norgren L (1994). "To what extent does peripheral vascular disease and hypertension predict renal artery stenosis?". Int Angiol. 13 (2): 109–14. PMID 7963868.