Runyon classification: Difference between revisions
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{{SI}} | {{SI}} | ||
{{Seealso|Nontuberculous mycobacteria}} | |||
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==Overview== | ==Overview== | ||
The '''Runyon classification''' of | The '''Runyon classification''' of [[nontuberculous mycobacteria]] based on the rate of growth, production of yellow pigment and whether this pigment was produced in the dark or only after exposure to light.<ref name="pmid2275850">{{cite journal |author=Rogall T, Wolters J, Flohr T, Böttger EC |title=Towards a phylogeny and definition of species at the molecular level within the genus Mycobacterium |journal=International journal of systematic bacteriology |volume=40 |issue=4 |pages=323–30 |date=October 1990 |pmid=2275850 |doi= 10.1099/00207713-40-4-323|url=}}</ref> It was introduced by Ernest Runyon in 1959.<ref name="pmid13612432">{{cite journal |author=Runyon EH |title=Anonymous mycobacteria in pulmonary disease |journal=The Medical clinics of North America |volume=43 |issue=1 |pages=273–90 |date=January 1959 |pmid=13612432 |doi= |url=}}</ref> On these bases, the [[nontuberculous mycobacteria]] are divided into four Runyon groups and the first three groups (Runyon I, II, and III) are classified as [[slowly growing mycobacteria]]. | ||
It was introduced by Ernest Runyon in 1959.<ref name="pmid13612432">{{cite journal |author=Runyon EH |title=Anonymous mycobacteria in pulmonary disease |journal=The Medical clinics of North America |volume=43 |issue=1 |pages=273–90 |date=January 1959 |pmid=13612432 |doi= |url=}}</ref> | |||
On these bases, the [[nontuberculous mycobacteria]] are divided into four groups | |||
==Runyon I: Photochromogens== | |||
Runyon I organisms ([[photochromogen]]s) are slow growing, and produce a yellow-orange pigment when exposed to light. The group includes | Runyon I organisms ([[photochromogen]]s) are slow growing, and produce a yellow-orange pigment when exposed to light. The group includes | ||
[[Mycobacterium kansasii]], [[Mycobacterium marinum]], [[Mycobacterium asiaticum]], and [[Mycobacterium simiae]]. [[Mycobacterium szulgai]] is a photochromogen when grown at 24 degrees, and a scotochromogen at 37 degrees. | [[Mycobacterium kansasii]], [[Mycobacterium marinum]], [[Mycobacterium asiaticum]], and [[Mycobacterium simiae]]. [[Mycobacterium szulgai]] is a photochromogen when grown at 24 degrees, and a scotochromogen at 37 degrees. | ||
==Runyon II: Scotochromogens== | |||
Runyon II organisms ([[scotochromogen]]s) are slow-growing and produce a yellow-orange pigment regardless of whether they are grown in the dark or the light. The group includes [[Mycobacterium Gordonae]] and [[Mycobacterium scrofulaceum]], among others. [[Mycobacterium szulgai]] is a scotochromogen when grown at 37 degrees, as mentioned above. | Runyon II organisms ([[scotochromogen]]s) are slow-growing and produce a yellow-orange pigment regardless of whether they are grown in the dark or the light. The group includes [[Mycobacterium Gordonae]] and [[Mycobacterium scrofulaceum]], among others. [[Mycobacterium szulgai]] is a scotochromogen when grown at 37 degrees, as mentioned above. | ||
==Runyon III: Nonchromogens== | |||
Runyon III organisms (nonchromogens) are slow-growing and never produce pigment, regardless of culture conditions. The group includes [[Mycobacterium avium]] and [[Mycobacterium intracellulare]] (together known as the MAI complex), and numerous other organisms. | Runyon III organisms (nonchromogens) are slow-growing and never produce pigment, regardless of culture conditions. The group includes [[Mycobacterium avium]] and [[Mycobacterium intracellulare]] (together known as the MAI complex), and numerous other organisms. | ||
==Runyon IV: | ==Runyon IV: Rapid Growers== | ||
Runyon IV organisms are rapid growing for mycobacteria (colonies in 5 days). They do not produce pigment. | Runyon IV organisms are rapid growing for mycobacteria (colonies in 5 days). They do not produce pigment. The group includes [[Mycobacterium fortuitum]], [[Mycobacterium peregrinum]], [[Mycobacterium abscessus]], [[Mycobacterium chelonae]], and [[Mycobacterium thermoresistibile]]. | ||
[[Mycobacterium fortuitum]], [[Mycobacterium peregrinum]], [[Mycobacterium abscessus]], [[Mycobacterium chelonae]], [[Mycobacterium thermoresistibile]] | |||
Some rapidly growing mycobacteria are considered "late-pigmenting".<ref>{{cite journal | pmid = 12364376 | pmc=126856 | volume=15 | issue=4 | title=Clinical and taxonomic status of pathogenic nonpigmented or late-pigmenting rapidly growing mycobacteria |date=October 2002 | journal=Clin. Microbiol. Rev. | pages=716–46 | author=Brown-Elliott BA, Wallace RJ | doi=10.1128/cmr.15.4.716-746.2002}}</ref> | Some rapidly growing mycobacteria are considered "late-pigmenting".<ref>{{cite journal | pmid = 12364376 | pmc=126856 | volume=15 | issue=4 | title=Clinical and taxonomic status of pathogenic nonpigmented or late-pigmenting rapidly growing mycobacteria |date=October 2002 | journal=Clin. Microbiol. Rev. | pages=716–46 | author=Brown-Elliott BA, Wallace RJ | doi=10.1128/cmr.15.4.716-746.2002}}</ref> |
Revision as of 21:17, 6 June 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
The Runyon classification of nontuberculous mycobacteria based on the rate of growth, production of yellow pigment and whether this pigment was produced in the dark or only after exposure to light.[1] It was introduced by Ernest Runyon in 1959.[2] On these bases, the nontuberculous mycobacteria are divided into four Runyon groups and the first three groups (Runyon I, II, and III) are classified as slowly growing mycobacteria.
Runyon I: Photochromogens
Runyon I organisms (photochromogens) are slow growing, and produce a yellow-orange pigment when exposed to light. The group includes Mycobacterium kansasii, Mycobacterium marinum, Mycobacterium asiaticum, and Mycobacterium simiae. Mycobacterium szulgai is a photochromogen when grown at 24 degrees, and a scotochromogen at 37 degrees.
Runyon II: Scotochromogens
Runyon II organisms (scotochromogens) are slow-growing and produce a yellow-orange pigment regardless of whether they are grown in the dark or the light. The group includes Mycobacterium Gordonae and Mycobacterium scrofulaceum, among others. Mycobacterium szulgai is a scotochromogen when grown at 37 degrees, as mentioned above.
Runyon III: Nonchromogens
Runyon III organisms (nonchromogens) are slow-growing and never produce pigment, regardless of culture conditions. The group includes Mycobacterium avium and Mycobacterium intracellulare (together known as the MAI complex), and numerous other organisms.
Runyon IV: Rapid Growers
Runyon IV organisms are rapid growing for mycobacteria (colonies in 5 days). They do not produce pigment. The group includes Mycobacterium fortuitum, Mycobacterium peregrinum, Mycobacterium abscessus, Mycobacterium chelonae, and Mycobacterium thermoresistibile.
Some rapidly growing mycobacteria are considered "late-pigmenting".[3]
References
- ↑ Rogall T, Wolters J, Flohr T, Böttger EC (October 1990). "Towards a phylogeny and definition of species at the molecular level within the genus Mycobacterium". International journal of systematic bacteriology. 40 (4): 323–30. doi:10.1099/00207713-40-4-323. PMID 2275850.
- ↑ Runyon EH (January 1959). "Anonymous mycobacteria in pulmonary disease". The Medical clinics of North America. 43 (1): 273–90. PMID 13612432.
- ↑ Brown-Elliott BA, Wallace RJ (October 2002). "Clinical and taxonomic status of pathogenic nonpigmented or late-pigmenting rapidly growing mycobacteria". Clin. Microbiol. Rev. 15 (4): 716–46. doi:10.1128/cmr.15.4.716-746.2002. PMC 126856. PMID 12364376.