Tinzaparin

Tinzaparin
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2]

Disclaimer

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Black Box Warning

SPINAL/EPIDURAL HEMATOMAS See full prescribing information for complete Boxed Warning. Spinal/Epidural Hematomas: Epidural or spinal hematomas may occur in patients who are anticoagulated with low molecular weight heparins (LMWH) or heparinoids and are receiving neuraxial anesthesia or undergoing spinal puncture. These hematomas may result in long-term or permanent paralysis. Consider these risks when scheduling patients for spinal procedures. Factors that can increase the risk of developing epidural or spinal hematomas in these patients include: Use of indwelling epidural catheters Concomitant use of other drugs that affect hemostasis, such as non-steroidal anti-inflammatory drugs (NSAIDs), platelet inhibitors, other anticoagulants. A history of traumatic or repeated epidural or spinal punctures A history of spinal deformity or spinal surgery Monitor patients frequently for signs and symptoms of neurological impairment. If neurological compromise is noted, urgent treatment is necessary. Consider the benefits and risks before neuraxial intervention in patients anticoagulated or to be anticoagulated for thromboprophylaxis

Overview

Tinzaparin is a low molecular weight heparin that is FDA approved for the treatment of acute symptomatic deep vein thrombosis with or without pulmonary embolism. There is a Black Box Warning for this drug as shown here. Common adverse reactions include bleeding, erythema, increase liver function tests, neurologic pain.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

There is limited information regarding Tinzaparin FDA-Labeled Indications and Dosage (Adult) in the drug label.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Tinzaparin in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Tinzaparin in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding Tinzaparin FDA-Labeled Indications and Dosage (Pediatric) in the drug label.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Tinzaparin in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Tinzaparin in pediatric patients.

Contraindications

There is limited information regarding Tinzaparin Contraindications in the drug label.

Warnings

SPINAL/EPIDURAL HEMATOMAS See full prescribing information for complete Boxed Warning. Spinal/Epidural Hematomas: Epidural or spinal hematomas may occur in patients who are anticoagulated with low molecular weight heparins (LMWH) or heparinoids and are receiving neuraxial anesthesia or undergoing spinal puncture. These hematomas may result in long-term or permanent paralysis. Consider these risks when scheduling patients for spinal procedures. Factors that can increase the risk of developing epidural or spinal hematomas in these patients include: Use of indwelling epidural catheters Concomitant use of other drugs that affect hemostasis, such as non-steroidal anti-inflammatory drugs (NSAIDs), platelet inhibitors, other anticoagulants. A history of traumatic or repeated epidural or spinal punctures A history of spinal deformity or spinal surgery Monitor patients frequently for signs and symptoms of neurological impairment. If neurological compromise is noted, urgent treatment is necessary. Consider the benefits and risks before neuraxial intervention in patients anticoagulated or to be anticoagulated for thromboprophylaxis

There is limited information regarding Tinzaparin Warnings' in the drug label.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Tinzaparin Clinical Trials Experience in the drug label.

Postmarketing Experience

There is limited information regarding Tinzaparin Postmarketing Experience in the drug label.

Drug Interactions

There is limited information regarding Tinzaparin Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Tinzaparin in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Tinzaparin in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Tinzaparin during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Tinzaparin in women who are nursing.

Pediatric Use

There is no FDA guidance on the use of Tinzaparin in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Tinzaparin in geriatric settings.

Gender

There is no FDA guidance on the use of Tinzaparin with respect to specific gender populations.

Race

There is no FDA guidance on the use of Tinzaparin with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Tinzaparin in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Tinzaparin in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Tinzaparin in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Tinzaparin in patients who are immunocompromised.

Administration and Monitoring

Administration

There is limited information regarding Tinzaparin Administration in the drug label.

Monitoring

There is limited information regarding Tinzaparin Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Tinzaparin and IV administrations.

Overdosage

There is limited information regarding Tinzaparin overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

There is limited information regarding Tinzaparin Pharmacology in the drug label.

Mechanism of Action

There is limited information regarding Tinzaparin Mechanism of Action in the drug label.

Structure

There is limited information regarding Tinzaparin Structure in the drug label.

Pharmacodynamics

There is limited information regarding Tinzaparin Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Tinzaparin Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Tinzaparin Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Tinzaparin Clinical Studies in the drug label.

How Supplied

There is limited information regarding Tinzaparin How Supplied in the drug label.

Storage

There is limited information regarding Tinzaparin Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Tinzaparin Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Tinzaparin interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Tinzaparin Brand Names in the drug label.

Look-Alike Drug Names

There is limited information regarding Tinzaparin Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

Tinzaparin

Clinical data
ATC code	B01AB10 (WHO)
Identifiers
CAS Number	9041-08-1
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}

WikiDoc Resources for Tinzaparin
Articles
Most recent articles on Tinzaparin Most cited articles on Tinzaparin Review articles on Tinzaparin Articles on Tinzaparin in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Tinzaparin Images of Tinzaparin Photos of Tinzaparin Podcasts & MP3s on Tinzaparin Videos on Tinzaparin
Evidence Based Medicine
Cochrane Collaboration on Tinzaparin Bandolier on Tinzaparin TRIP on Tinzaparin
Clinical Trials
Ongoing Trials on Tinzaparin at Clinical Trials.gov Trial results on Tinzaparin Clinical Trials on Tinzaparin at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Tinzaparin NICE Guidance on Tinzaparin NHS PRODIGY Guidance FDA on Tinzaparin CDC on Tinzaparin
Books
Books on Tinzaparin
News
Tinzaparin in the news Be alerted to news on Tinzaparin News trends on Tinzaparin
Commentary
Blogs on Tinzaparin
Definitions
Definitions of Tinzaparin
Patient Resources / Community
Patient resources on Tinzaparin Discussion groups on Tinzaparin Patient Handouts on Tinzaparin Directions to Hospitals Treating Tinzaparin Risk calculators and risk factors for Tinzaparin
Healthcare Provider Resources
Symptoms of Tinzaparin Causes & Risk Factors for Tinzaparin Diagnostic studies for Tinzaparin Treatment of Tinzaparin
Continuing Medical Education (CME)
CME Programs on Tinzaparin
International
Tinzaparin en Espanol Tinzaparin en Francais
Business
Tinzaparin in the Marketplace Patents on Tinzaparin
Experimental / Informatics
List of terms related to Tinzaparin

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]