Ebola classification: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
Joao Silva (talk | contribs) |
||
| Line 45: | Line 45: | ||
==Classification by Virus Type== | ==Classification by Virus Type== | ||
=====''Zaïre | =====''Zaïre Ebola virus''===== | ||
*Among the five [[strains]], ''Zaïre Ebolavirus'' carries the highest [[mortality rate]]. | *Among the five [[strains]], ''Zaïre Ebolavirus'' carries the highest [[mortality rate]]. | ||
*A [[virus]] of the genus ''[[Ebolavirus]]'' is considered member of the [[species]] ''Zaire ebolavirus'' if:<ref name="KuhnBecker2010">{{cite journal|last1=Kuhn|first1=Jens H.|last2=Becker|first2=Stephan|last3=Ebihara|first3=Hideki|last4=Geisbert|first4=Thomas W.|last5=Johnson|first5=Karl M.|last6=Kawaoka|first6=Yoshihiro|last7=Lipkin|first7=W. Ian|last8=Negredo|first8=Ana I.|last9=Netesov|first9=Sergey V.|last10=Nichol|first10=Stuart T.|last11=Palacios|first11=Gustavo|last12=Peters|first12=Clarence J.|last13=Tenorio|first13=Antonio|last14=Volchkov|first14=Viktor E.|last15=Jahrling|first15=Peter B.|title=Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations|journal=Archives of Virology|volume=155|issue=12|year=2010|pages=2083–2103|issn=0304-8608|doi=10.1007/s00705-010-0814-x}}</ref> | *A [[virus]] of the genus ''[[Ebolavirus]]'' is considered member of the [[species]] ''Zaire ebolavirus'' if:<ref name="KuhnBecker2010">{{cite journal|last1=Kuhn|first1=Jens H.|last2=Becker|first2=Stephan|last3=Ebihara|first3=Hideki|last4=Geisbert|first4=Thomas W.|last5=Johnson|first5=Karl M.|last6=Kawaoka|first6=Yoshihiro|last7=Lipkin|first7=W. Ian|last8=Negredo|first8=Ana I.|last9=Netesov|first9=Sergey V.|last10=Nichol|first10=Stuart T.|last11=Palacios|first11=Gustavo|last12=Peters|first12=Clarence J.|last13=Tenorio|first13=Antonio|last14=Volchkov|first14=Viktor E.|last15=Jahrling|first15=Peter B.|title=Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations|journal=Archives of Virology|volume=155|issue=12|year=2010|pages=2083–2103|issn=0304-8608|doi=10.1007/s00705-010-0814-x}}</ref> | ||
| Line 52: | Line 52: | ||
:*It has a [[genomic sequence]] that differs from the type [[virus]] by less than 30%. | :*It has a [[genomic sequence]] that differs from the type [[virus]] by less than 30%. | ||
=====''Sudan | =====''Sudan Ebola virus''===== | ||
*A [[virus]] of the genus ''[[Ebolavirus]]'' is considered member of the [[species]] ''Sudan ebolavirus'' if:<ref name="KuhnBecker2010">{{cite journal|last1=Kuhn|first1=Jens H.|last2=Becker|first2=Stephan|last3=Ebihara|first3=Hideki|last4=Geisbert|first4=Thomas W.|last5=Johnson|first5=Karl M.|last6=Kawaoka|first6=Yoshihiro|last7=Lipkin|first7=W. Ian|last8=Negredo|first8=Ana I.|last9=Netesov|first9=Sergey V.|last10=Nichol|first10=Stuart T.|last11=Palacios|first11=Gustavo|last12=Peters|first12=Clarence J.|last13=Tenorio|first13=Antonio|last14=Volchkov|first14=Viktor E.|last15=Jahrling|first15=Peter B.|title=Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations|journal=Archives of Virology|volume=155|issue=12|year=2010|pages=2083–2103|issn=0304-8608|doi=10.1007/s00705-010-0814-x}}</ref> | *A [[virus]] of the genus ''[[Ebolavirus]]'' is considered member of the [[species]] ''Sudan ebolavirus'' if:<ref name="KuhnBecker2010">{{cite journal|last1=Kuhn|first1=Jens H.|last2=Becker|first2=Stephan|last3=Ebihara|first3=Hideki|last4=Geisbert|first4=Thomas W.|last5=Johnson|first5=Karl M.|last6=Kawaoka|first6=Yoshihiro|last7=Lipkin|first7=W. Ian|last8=Negredo|first8=Ana I.|last9=Netesov|first9=Sergey V.|last10=Nichol|first10=Stuart T.|last11=Palacios|first11=Gustavo|last12=Peters|first12=Clarence J.|last13=Tenorio|first13=Antonio|last14=Volchkov|first14=Viktor E.|last15=Jahrling|first15=Peter B.|title=Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations|journal=Archives of Virology|volume=155|issue=12|year=2010|pages=2083–2103|issn=0304-8608|doi=10.1007/s00705-010-0814-x}}</ref> | ||
:*It is [[endemic]] in Sudan and/or Uganda. | :*It is [[endemic]] in Sudan and/or Uganda. | ||
| Line 58: | Line 58: | ||
:*It has a [[genomic]] sequence different from ''[[Ebola virus]]'' by ≥30%, but different from that of Sudan [[virus]] by <30%. | :*It has a [[genomic]] sequence different from ''[[Ebola virus]]'' by ≥30%, but different from that of Sudan [[virus]] by <30%. | ||
=====''Reston | =====''Reston Ebola virus''===== | ||
*A [[virus]] of the [[genus]] ''[[Ebolavirus]]'' is considered member of the [[species]] ''Reston ebolavirus'' if:<ref name="KuhnBecker2010">{{cite journal|last1=Kuhn|first1=Jens H.|last2=Becker|first2=Stephan|last3=Ebihara|first3=Hideki|last4=Geisbert|first4=Thomas W.|last5=Johnson|first5=Karl M.|last6=Kawaoka|first6=Yoshihiro|last7=Lipkin|first7=W. Ian|last8=Negredo|first8=Ana I.|last9=Netesov|first9=Sergey V.|last10=Nichol|first10=Stuart T.|last11=Palacios|first11=Gustavo|last12=Peters|first12=Clarence J.|last13=Tenorio|first13=Antonio|last14=Volchkov|first14=Viktor E.|last15=Jahrling|first15=Peter B.|title=Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations|journal=Archives of Virology|volume=155|issue=12|year=2010|pages=2083–2103|issn=0304-8608|doi=10.1007/s00705-010-0814-x}}</ref> | *A [[virus]] of the [[genus]] ''[[Ebolavirus]]'' is considered member of the [[species]] ''Reston ebolavirus'' if:<ref name="KuhnBecker2010">{{cite journal|last1=Kuhn|first1=Jens H.|last2=Becker|first2=Stephan|last3=Ebihara|first3=Hideki|last4=Geisbert|first4=Thomas W.|last5=Johnson|first5=Karl M.|last6=Kawaoka|first6=Yoshihiro|last7=Lipkin|first7=W. Ian|last8=Negredo|first8=Ana I.|last9=Netesov|first9=Sergey V.|last10=Nichol|first10=Stuart T.|last11=Palacios|first11=Gustavo|last12=Peters|first12=Clarence J.|last13=Tenorio|first13=Antonio|last14=Volchkov|first14=Viktor E.|last15=Jahrling|first15=Peter B.|title=Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations|journal=Archives of Virology|volume=155|issue=12|year=2010|pages=2083–2103|issn=0304-8608|doi=10.1007/s00705-010-0814-x}}</ref> | ||
:*If its [[genome]] diverges from that of the prototype ''Reston [[virus]]'', the ''Reston virus'' variant Pennsylvania, by ≤10% at the [[nucleotide]] level. | :*If its [[genome]] diverges from that of the prototype ''Reston [[virus]]'', the ''Reston virus'' variant Pennsylvania, by ≤10% at the [[nucleotide]] level. | ||
=====''Tai (Ivory Coast) | =====''Tai (Ivory Coast) Ebola virus''===== | ||
*A [[virus]] of the [[genus]] ''[[Ebolavirus]]'' is considered member of the [[species]] ''Tai Forest ebolavirus'' if:<ref name="KuhnBecker2010">{{cite journal|last1=Kuhn|first1=Jens H.|last2=Becker|first2=Stephan|last3=Ebihara|first3=Hideki|last4=Geisbert|first4=Thomas W.|last5=Johnson|first5=Karl M.|last6=Kawaoka|first6=Yoshihiro|last7=Lipkin|first7=W. Ian|last8=Negredo|first8=Ana I.|last9=Netesov|first9=Sergey V.|last10=Nichol|first10=Stuart T.|last11=Palacios|first11=Gustavo|last12=Peters|first12=Clarence J.|last13=Tenorio|first13=Antonio|last14=Volchkov|first14=Viktor E.|last15=Jahrling|first15=Peter B.|title=Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations|journal=Archives of Virology|volume=155|issue=12|year=2010|pages=2083–2103|issn=0304-8608|doi=10.1007/s00705-010-0814-x}}</ref> | *A [[virus]] of the [[genus]] ''[[Ebolavirus]]'' is considered member of the [[species]] ''Tai Forest ebolavirus'' if:<ref name="KuhnBecker2010">{{cite journal|last1=Kuhn|first1=Jens H.|last2=Becker|first2=Stephan|last3=Ebihara|first3=Hideki|last4=Geisbert|first4=Thomas W.|last5=Johnson|first5=Karl M.|last6=Kawaoka|first6=Yoshihiro|last7=Lipkin|first7=W. Ian|last8=Negredo|first8=Ana I.|last9=Netesov|first9=Sergey V.|last10=Nichol|first10=Stuart T.|last11=Palacios|first11=Gustavo|last12=Peters|first12=Clarence J.|last13=Tenorio|first13=Antonio|last14=Volchkov|first14=Viktor E.|last15=Jahrling|first15=Peter B.|title=Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations|journal=Archives of Virology|volume=155|issue=12|year=2010|pages=2083–2103|issn=0304-8608|doi=10.1007/s00705-010-0814-x}}</ref> | ||
:*It is [[endemic]] in Côte d'Ivoire. | :*It is [[endemic]] in Côte d'Ivoire. | ||
| Line 68: | Line 68: | ||
:*It has a [[genomic]] sequence different from ''[[Ebola virus]]'' by ≥30% but different from that of Tai Forest [[virus]] by <30%. | :*It has a [[genomic]] sequence different from ''[[Ebola virus]]'' by ≥30% but different from that of Tai Forest [[virus]] by <30%. | ||
=====''Bundibugyo | =====''Bundibugyo Ebola virus''===== | ||
*A [[virus]] of the [[genus]] ''[[Ebolavirus]]'' is considered member of the [[species]] ''Bundibugyo ebolavirus'' if:<ref name="KuhnBecker2010">{{cite journal|last1=Kuhn|first1=Jens H.|last2=Becker|first2=Stephan|last3=Ebihara|first3=Hideki|last4=Geisbert|first4=Thomas W.|last5=Johnson|first5=Karl M.|last6=Kawaoka|first6=Yoshihiro|last7=Lipkin|first7=W. Ian|last8=Negredo|first8=Ana I.|last9=Netesov|first9=Sergey V.|last10=Nichol|first10=Stuart T.|last11=Palacios|first11=Gustavo|last12=Peters|first12=Clarence J.|last13=Tenorio|first13=Antonio|last14=Volchkov|first14=Viktor E.|last15=Jahrling|first15=Peter B.|title=Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations|journal=Archives of Virology|volume=155|issue=12|year=2010|pages=2083–2103|issn=0304-8608|doi=10.1007/s00705-010-0814-x}}</ref> | *A [[virus]] of the [[genus]] ''[[Ebolavirus]]'' is considered member of the [[species]] ''Bundibugyo ebolavirus'' if:<ref name="KuhnBecker2010">{{cite journal|last1=Kuhn|first1=Jens H.|last2=Becker|first2=Stephan|last3=Ebihara|first3=Hideki|last4=Geisbert|first4=Thomas W.|last5=Johnson|first5=Karl M.|last6=Kawaoka|first6=Yoshihiro|last7=Lipkin|first7=W. Ian|last8=Negredo|first8=Ana I.|last9=Netesov|first9=Sergey V.|last10=Nichol|first10=Stuart T.|last11=Palacios|first11=Gustavo|last12=Peters|first12=Clarence J.|last13=Tenorio|first13=Antonio|last14=Volchkov|first14=Viktor E.|last15=Jahrling|first15=Peter B.|title=Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations|journal=Archives of Virology|volume=155|issue=12|year=2010|pages=2083–2103|issn=0304-8608|doi=10.1007/s00705-010-0814-x}}</ref> | ||
:*It is [[endemic]] in Uganda. | :*It is [[endemic]] in Uganda. | ||
Revision as of 15:00, 16 July 2014
|
Ebola Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Postmortem Care |
|
Case Studies |
|
Ebola classification On the Web |
|
American Roentgen Ray Society Images of Ebola classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Guillermo Rodriguez Nava, M.D. [2]; João André Alves Silva, M.D. [3]
Overview
Ebola virus can be classified into 5 subtypes: Zaïre, Sudan, Reston, Tai (Ivory Coast) and Bundibugyo.
The table below summarizes the ebola virus strains identified until now:
| Ebola Virus Strain | Place of Discovery | Date Identified |
|---|---|---|
| Sudan ebolavirus | Nzara and Maridi, Sudan | Between June and November 1976 |
| Zaire ebolavirus | Yambuku, Democratic Republic of the Congo | Between August and November 1976 |
| Reston ebolavirus | Reston, Virginia, US. | November 1989 |
| Ivory Coast ebolavirus | Tai Forest, Ivory Coast. | November 1994 |
| Bundibugyo ebolavirus | Bundibugyo District, Uganda | November 2007 |
Classification by Suspected vs Confirmed Case
The standard case definition recommended by the WHO-AFRO for the notification of Ebola or Marburg cases is as follows:[1]
Suspected Ebola or Marburg cases for routine surveillance
- Disease that presents with onset of fever, no response to empiric therapy of fever for that region, and at least one of the following signs:
Confirmed Ebola or Marburg cases for routine surveillance
A suspected case with laboratory confirmation (positive IgM antibody, positive PCR or viral isolation)
Classification by Virus Type
Zaïre Ebola virus
- Among the five strains, Zaïre Ebolavirus carries the highest mortality rate.
- A virus of the genus Ebolavirus is considered member of the species Zaire ebolavirus if:[2]
- It is found in the Democratic Republic of the Congo, Gabon, or the Republic of the Congo.
- It has a genome with two or three gene overlaps (VP35/VP40, GP/VP30, VP24/L).
- It has a genomic sequence that differs from the type virus by less than 30%.
Sudan Ebola virus
- A virus of the genus Ebolavirus is considered member of the species Sudan ebolavirus if:[2]
Reston Ebola virus
- A virus of the genus Ebolavirus is considered member of the species Reston ebolavirus if:[2]
- If its genome diverges from that of the prototype Reston virus, the Reston virus variant Pennsylvania, by ≤10% at the nucleotide level.
Tai (Ivory Coast) Ebola virus
- A virus of the genus Ebolavirus is considered member of the species Tai Forest ebolavirus if:[2]
Bundibugyo Ebola virus
- A virus of the genus Ebolavirus is considered member of the species Bundibugyo ebolavirus if:[2]
- It is endemic in Uganda.
- It has a genome with three gene overlaps (VP35/VP40, GP/VP30, VP24/L).
- It has a genomic sequence different from Ebola virus by ≥30%, but different from that of Bundibugyo virus by <30%.
References
- ↑ "Case definition recommendations for Ebola or Marburg Virus Diseases" (PDF).
- ↑ 2.0 2.1 2.2 2.3 2.4 Kuhn, Jens H.; Becker, Stephan; Ebihara, Hideki; Geisbert, Thomas W.; Johnson, Karl M.; Kawaoka, Yoshihiro; Lipkin, W. Ian; Negredo, Ana I.; Netesov, Sergey V.; Nichol, Stuart T.; Palacios, Gustavo; Peters, Clarence J.; Tenorio, Antonio; Volchkov, Viktor E.; Jahrling, Peter B. (2010). "Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations". Archives of Virology. 155 (12): 2083–2103. doi:10.1007/s00705-010-0814-x. ISSN 0304-8608.