Anthrax laboratory findings: Difference between revisions

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Revision as of 23:29, 16 July 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

The following tests are used in the diagnosis and monitoring of systemic anthrax:^[1]

**Laboratory findings**
Test	Initial Findings	Serial Monitoring
CBC	Hemoconcentration Possible Thrombocytopenia Leukocyte count commonly normal	Anemia Thrombocytopenia Leukocytosis (late in disease)
Electrolyte, Renal Panel, Lactate Level	Decreased Sodium level Increased BUN
Liver Enzymes, Serum Albumin	Elevated transaminase levels hypoalbuminemia
PT, PTT, D-dimer, Fibrinogen	Normal PT/PTT does not exclude DIC or coagulopathy	Low threshold for hypercoagulability workup: Haptoglobin LDH Fibrin split products ADAMTS 13 if hemolytic anemia
C-Reactive Protein	Characterization of Inflammatory Response Typically low CRP in injection anthrax
Gram stain, Cultures, Toxic Assays	Blood Serum CSF Pleural fluid Ascites Wound exudate Bronchial exudate	Cultures usually negative after antibiotics Toxins may be detected

↑ Hendricks, Katherine A.; Wright, Mary E.; Shadomy, Sean V.; Bradley, John S.; Morrow, Meredith G.; Pavia, Andy T.; Rubinstein, Ethan; Holty, Jon-Erik C.; Messonnier, Nancy E.; Smith, Theresa L.; Pesik, Nicki; Treadwell, Tracee A.; Bower, William A. (2014). "Centers for Disease Control and Prevention Expert Panel Meetings on Prevention and Treatment of Anthrax in Adults". Emerging Infectious Diseases. 20 (2). doi:10.3201/eid2002.130687. ISSN 1080-6040.

@@ Line 20: / Line 20: @@
 |-
 | style="background: #F5F5F5; padding: 5px; text-align: center;"| '''[[Electrolyte]], [[Renal]] Panel, [[Lactate]] Level'''
-| style="background: #DCDCDC; padding: 5px;"| Decreased [[Na+]] level<br>Increased [[BUN]]
+| style="background: #DCDCDC; padding: 5px;"| Decreased [[Sodium]] level<br>Increased [[BUN]]
 | style="background: #DCDCDC; padding: 5px;"|
 |-
@@ Line 36: / Line 36: @@
 |-
-| style="background: #F5F5F5; padding: 5px; text-align: center;"| '''[[Gram Stain]], [[Cell cultures|Cultures]], Toxic Assays'''
+| style="background: #F5F5F5; padding: 5px; text-align: center;"| '''[[Gram stain]], Cultures, Toxic Assays'''
 | style="background: #DCDCDC; padding: 5px;"| [[Blood]]<br>[[Serum]]<br>[[CSF]]<br>[[Pleural fluid]]<br>[[Ascites]]<br>Wound [[exudate]]<br>[[Bronchial]] [[exudate]]
 | style="background: #DCDCDC; padding: 5px;"| Cultures usually negative after [[antibiotics]]<br>[[Toxins]] may be detected