Anthrax laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
Laboratory tests for the [[diagnosis]] of [[anthrax]] include [[CBC]], [[Sodium]] level, [[liver]] enzymes, [[coagulation]] workup, inflammatory markers | Laboratory tests for the [[diagnosis]] of [[anthrax]] include [[CBC]], [[Sodium]] level, [[liver]] enzymes, [[coagulation]] workup, inflammatory markers, [[gram stain]] and cultures of different specimens and [[cardiac]] enzymes. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
Revision as of 23:58, 16 July 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
Laboratory tests for the diagnosis of anthrax include CBC, Sodium level, liver enzymes, coagulation workup, inflammatory markers, gram stain and cultures of different specimens and cardiac enzymes.
Laboratory Findings
The following tests are used in the diagnosis and monitoring of systemic anthrax:[1]
| Test | Initial Findings | Serial Monitoring |
|---|---|---|
| CBC | Hemoconcentration Possible Thrombocytopenia Leukocyte count commonly normal |
Anemia Thrombocytopenia Leukocytosis (late in disease) |
| Electrolyte Renal Panel Lactate Level |
Decreased Sodium level Increased BUN | |
| Liver Enzymes Serum Albumin |
Elevated transaminase levels hypoalbuminemia | |
| PT PTT D-dimer Fibrinogen |
Normal PT/PTT does not exclude DIC or coagulopathy | Low threshold for hypercoagulability workup: Haptoglobin LDH Fibrin split products ADAMTS 13 if hemolytic anemia |
| C-Reactive Protein | Characterization of Inflammatory Response Typically low CRP in injection anthrax | |
| Gram stain Cultures Toxic Assays |
Blood Serum CSF Pleural fluid Ascites Wound exudate Bronchial exudate |
Cultures usually negative after antibiotics Toxins may be detected |
| Cardiac Enzymes BNP |
Troponin leak caused by increased cardiac demand from infection (particularly if atrial fibrillation with rapid ventricular response | |
References
- ↑ Hendricks, Katherine A.; Wright, Mary E.; Shadomy, Sean V.; Bradley, John S.; Morrow, Meredith G.; Pavia, Andy T.; Rubinstein, Ethan; Holty, Jon-Erik C.; Messonnier, Nancy E.; Smith, Theresa L.; Pesik, Nicki; Treadwell, Tracee A.; Bower, William A. (2014). "Centers for Disease Control and Prevention Expert Panel Meetings on Prevention and Treatment of Anthrax in Adults". Emerging Infectious Diseases. 20 (2). doi:10.3201/eid2002.130687. ISSN 1080-6040.