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Non-prescription dosing, 200 to 400 mg orally every 4 to 6 hours as needed; maximum of 1200 mg/day. Do not take longer than 10 days unless directed by physician.
Headache
Dosing Information
Non-prescription dose recommendations are 200 to 400 mg orally ever 4 to 6 hours as needed; Maximum dose, 1200 mg in 24 hours
Migraine
Dosing Information
Non-prescription dose recommendations are 200 to 400 mg orally ever 4 to 6 hours as needed; Maximum dose, 1200 mg in 24 hours.
Osteoarthritis
Dosing Information
For osteoarthritis, the recommended dosage range is 1200 to 3200 mg daily; this may be given as 300 mg 4 times daily or as 400 mg, 600 mg, or 800 mg 3 or 4 times daily. Patients with rheumatoid arthritis often respond better to higher doses.
Sustained release preparations (Ibu-Slo(R), Rounlats, England; Fenlong(R), Sol Pharmaceuticals, India) in doses of 600 mg twice daily have been as effective as regular release preparations administered 400 mg three times daily.
Non-prescription ibuprofen should not be taken for longer than 10 days unless directed by a physician. The smallest effective dose should be used.
Pain
Dosing Information
Usual dose: 400 mg every 4 to 6 hours as needed; doses greater than 400 mg usually do not provide greater analgesic activity
Nonprescription ibuprofen should not be taken for longer than 10 days unless directed by a physician. The smallest effective dose should be used
Primary dysmenorrhea
Dosing Information
Usual dose: 400 mg every 4 to 6 hours as needed; doses greater than 400 mg usually do not provide greater analgesic activity.
Nonprescription ibuprofen should not be taken for longer than 10 days unless directed by a physician. The smallest effective dose should be used.
Rheumatoid arthritis
Dosing Information
For rheumatoid arthritis, the recommended dosage range is 1200 to 3200 mg daily; this may be given as 300 mg 4 times daily or as 400 mg, 600 mg, or 800 mg 3 or 4 times daily. Patients with rheumatoid arthritis often respond better to higher doses.
Sustained release preparations (Ibu-Slo(R), Rounlats, England; Fenlong(R), Sol Pharmaceuticals, India) in doses of 600 mg twice daily have been as effective as regular release preparations administered 400 mg three times daily.
Non-prescription ibuprofen should not be taken for longer than 10 days unless directed by a physician. The smallest effective dose should be used.
Non-Prescription:
The recommended dosage for non-prescription ibuprofen is 200 mg every 4 to 6 hours while symptoms persist. If no response occurs with the 200-mg dose, 400 mg may be taken; however, the maximum dose should not exceed 1200 mg/day (Prod Info Motrin IB(R), 1999).
Non-prescription ibuprofen should not be taken for longer than 10 days unless directed by a physician. The smallest effective dose should be used.
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
Condition1
Developed by:
Class of Recommendation:
Strength of Evidence:
Dosing Information
Dosage
Condition2
There is limited information regarding Off-Label Guideline-Supported Use of Ibuprofen (oral) in adult patients.
Non–Guideline-Supported Use
Condition1
Dosing Information
Dosage
Condition2
There is limited information regarding Off-Label Non–Guideline-Supported Use of Ibuprofen (oral) in adult patients.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
Fever
Dosing Information
The recommended dose for the treatment of fever in pediatric patients age 17 years and older is ibuprofen 400 mg IV every 4 to 6 hours. Alternatively, 100 to 200 mg IV every 4 hours may be used. The infusion should last at least 30 minutes.
Headache
Dosing Information
The recommended dose of oral suspension in pediatric patients age 6 months to 2 years of age: dosing depends on weight and age, administer each dose orally every 6 to 8 hours as needed. For 12 to 17 pounds or 6 to 11 months of age, 50 mg For 18 to 23 pounds or 12 to 23 months of age, 75 mg; Maximum of doses/day.
The recommended dose of oral suspension in pediatric patients age 2 years and older: dosing depends on weight and age, administer each dose orally every 6 to 8 hour as needed. For 24 to 35 pounds or 2 to 3 years of age, the recommended dose is 100 mg. For 36 to 47 pounds or 4 to 5 years of age, the recommended dose is 150 mg. For 48 to 59 pounds or 6 to 8 years of age, the dose is 200 mg; for 60 to 71 pounds or 9 to 10 years of age, 250 mg; and for 72 to 95 pounds or 11 years of age, 300 mg. Maximum is 4 doses/day.
The recommended dose of oral tablets in pediatric patients age 12 years and older is 200 to 400 mg orally every 4 to 6 hours as needed. Maximum dose is 1200 mg in 24 hours.
Pain
Dosing Information
Usual dose: 4 to 10 mg/kg/dose repeated every 6 to 8 hours as needed
Nonprescription ibuprofen should not be taken for longer than 10 days unless directed by a physician. Do not give more than directed.
Primary dysmenorrhea
Rheumatoid arthritis
Dosing Information
The usual dosage range for treating juvenile rheumatoid arthritis is 30 to 50 mg/kg/day divided into four doses. The maximum recommended dose is 2.4 g/day.
Ibuprofen suspension is effective with acceptable tolerability in the treatment of JRA (juvenile rheumatoid arthritis). Ibuprofen in doses of 30 to 40 mg/kg/day was as effective as aspirin 60 to 80 mg/kg/day in a 12-week trial in 92 children with JRA; no significant differences were observed. In a 24-week open trial, favorable response rates were observed in children with JRA receiving ibuprofen 30, 40 and 50 mg/kg/day.
Non-prescription ibuprofen should not be given for longer than 10 days unless directed by a physician. Do not give more than directed.
Non-Prescription:
For use as an analgesic and antipyretic, the recommended dosage for children 6 months to 11 years of age is 7.5 mg/kg. This dose may be repeated every 6 to 8 hours. The maximum recommended dose is 30 mg/kg/day.
Non-prescription ibuprofen should not be taken for longer than 10 days unless directed by a physician. Do not give more than directed.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Ibuprofen in pediatric patients.
Non–Guideline-Supported Use
Patent ductus arteriosus
Dosing Information
Study dose in premature infants younger than 37 weeks gestational age: 10 mg/kg orally, followed by 5 mg/kg orally every 24 hours for 2 doses.
Contraindications
There is limited information regarding Ibuprofen (oral) Contraindications in the drug label.
Warnings
Allergy alert:
Ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include:
hives
facial swelling
asthma (wheezing)
shock
skin reddening
rash
blisters
If an allergic reaction occurs, stop use and seek medical help right away.
Stomach bleeding warning:
This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you
are age 60 or older
have had stomach ulcers or bleeding problems
take a blood thinning (anticoagulant) or steroid drug
take other drugs containing prescription or non-prescription NSAIDs [aspirin, ibuprofen, naproxen, or others]
have 3 or more alcoholic drinks every day while using this product
take more or for a longer time than directed
Do not use
if you have ever had an allergic reaction to any other pain reliever/fever reducer
right before or after heart surgery
Ask a doctor before use if
stomach bleeding warning applies to you
you have problems or serious side effects from taking pain relievers or fever reducers
you have a history of stomach problems, such as heartburn
you have high blood pressure, heart disease, liver cirrhosis, kidney disease, or asthma
you are taking a diuretic
Ask a doctor or pharmacist before use if you are
under a doctor's care for any serious condition
taking aspirin for heart attack or stroke, because ibuprofen may decrease this benefit of aspirin
taking any other drug
When using this product
take with food or milk if stomach upset occurs
the risk of heart attack or stroke may increase if you use more than directed or for longer than directed
Stop use and ask a doctor if
you experience any of the following signs of stomach bleeding:
feel faint
vomit blood
have bloody or black stools
have stomach pain that does not get better
pain gets worse or lasts more than 10 days
fever gets worse or lasts more than 3 days
redness or swelling is present in the painful area
any new symptoms appear
If pregnant or breast-feeding,
ask a health professional before use. It is especially important not to use ibuprofen during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.
Keep out of reach of children.
In case of overdose, get medical help or contact a Poison Control Center right away.
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Clinical Trial Experience of Ibuprofen (oral) in the drug label.
Postmarketing Experience
There is limited information regarding Postmarketing Experience of Ibuprofen (oral) in the drug label.
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