Hypertrophic cardiomyopathy causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ogheneochuko Ajari, MB.BS, MS [2]

Overview

Hypertrophic cardiomyopathy is a condition that is most often passed down through families (inherited). It is thought to result from gene mutations that control heart muscle growth.

Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

Common Causes

Causes by Organ System

Cardiovascular	Atrial myxoma, cardiofaciocutaneous syndrome, congenital generalized lipodystrophy type 2, Costello syndrome, hypertension, hypertrichotic osteochondrodysplasia, Noonan syndrome, subendocardial ischemia, very long-chain acyl-CoA dehydrogenase deficiency, Yunis-Varon syndrome
Chemical / poisoning	No underlying causes
Dermatologic	Cardiofaciocutaneous syndrome, congenital generalized lipodystrophy type 2, Yunis-Varon syndrome
Drug Side Effect	No underlying causes
Ear Nose Throat	No underlying causes
Endocrine	Diabetes mellitus, glycogenosis type 2, thyroid disease
Environmental	No underlying causes
Gastroenterologic	Glycogenosis type 2, very long-chain acyl-CoA dehydrogenase deficiency
Genetic	Cardiofaciocutaneous syndrome, congenital generalized lipodystrophy type 2, Costello syndrome, cytochrome c oxidase deficiency, Fabry's disease, familial, Friedreich's ataxia, gene mutation, glycogenosis type 2, long-chain acyl-CoA dehydrogenase deficiency, malonyl-CoA decarboxylase deficiency, MELAS, multiple lentigines syndrome, myotonic dystrophy, Noonan syndrome, sarcomeric protein mutations
Hematologic	Hereditary spherocytosis
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal / Ortho	Hypertrichotic osteochondrodysplasia, myotonic dystrophy, Yunis-Varon syndrome
Neurologic	Friedreich's ataxia, MELAS, myotonic dystrophy
Nutritional / Metabolic	Cytochrome c oxidase deficiency, dihydrolipoamide dehydrogenase deficiency, Fabry's disease, long-chain acyl-CoA dehydrogenase deficiency, malonyl-CoA decarboxylase deficiency, MELAS, muscle glycogen synthase deficiency, very long-chain acyl-CoA dehydrogenase deficiency
Obstetric/Gynecologic	No underlying causes
Oncologic	No underlying causes
Opthalmologic	No underlying causes
Overdose / Toxicity	No underlying causes
Psychiatric	Costello syndrome, hypertrichotic osteochondrodysplasia
Pulmonary	No underlying causes
Renal / Electrolyte	No underlying causes
Rheum / Immune / Allergy	No underlying causes
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	Aging, idiopathic

Causes in Alphabetical Order

Aging
Atrial myxoma^[1]
Cardiofaciocutaneous syndrome
Congenital generalized lipodystrophy type 2
Costello syndrome ^[2]
Cytochrome c oxidase deficiency
Diabetes mellitus
Dihydrolipoamide dehydrogenase deficiency
Fabry's disease^[3]
Familial
Friedreich's ataxia^[4]
Gene mutation
Glycogenosis type 2
Hereditary spherocytosis
Hypertension
Hypertrichotic osteochondrodysplasia
Hypertrophic obstructive cardiomyopathy
Idiopathic
Long-chain acyl-CoA dehydrogenase deficiency
Malonyl-CoA decarboxylase deficiency
MELAS
Multiple lentigines syndrome
Muscle glycogen synthase deficiency
Myotonic dystrophy^[5]
Noonan syndrome^[6]
Sarcomeric protein mutations
Subendocardial ischemia
Thyroid disease
Very long-chain acyl-CoA dehydrogenase deficiency^[7]
Yunis-Varon syndrome

References

↑ Abdou M, Hayek S, Williams BR (2013). "Atrial myxoma in a patient with hypertrophic cardiomyopathy". Tex Heart Inst J. 40 (4): 462–4. PMC 3783132. PMID 24082380.
↑ Fukao T, Sakai S, Shimozawa N, Kuwahara T, Kano M, Goto E; et al. (1996). "Life-threatening cardiac involvement throughout life in a case of Costello syndrome". Clin Genet. 50 (4): 244–7. PMID 9001809.
↑ Adam T, Alexandrescu L, Voinea F, Toringhibel M, Hâncu A (2006). "Fabry's disease". Rom J Intern Med. 44 (4): 455–64. PMID 18386622.
↑ Jauslin ML, Wirth T, Meier T, Schoumacher F (2002). "A cellular model for Friedreich Ataxia reveals small-molecule glutathione peroxidase mimetics as novel treatment strategy". Hum Mol Genet. 11 (24): 3055–63. PMID 12417527.
↑ Halawa A, Iskandar SB, Brahmbhatt V, Fahrig SA (2007). "Atrial flutter and myotonic dystrophy in a male adolescent treated with radiofrequency catheter ablation". Rev Cardiovasc Med. 8 (2): 118–22. PMID 17603429.
↑ Prendiville TW, Gauvreau K, Tworog-Dube E, Patkin L, Kucherlapati RS, Roberts AE; et al. (2014). "Cardiovascular disease in Noonan syndrome". Arch Dis Child. 99 (7): 629–34. doi:10.1136/archdischild-2013-305047. PMID 24534818.
↑ Tucci S, Flögel U, Hermann S, Sturm M, Schäfers M, Spiekerkoetter U (2014). "Development and pathomechanisms of cardiomyopathy in very long-chain acyl-CoA dehydrogenase deficient (VLCAD(-/-)) mice". Biochim Biophys Acta. 1842 (5): 677–85. doi:10.1016/j.bbadis.2014.02.001. PMID 24530811.

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[pmid24082380-1] Abdou M, Hayek S, Williams BR (2013). "Atrial myxoma in a patient with hypertrophic cardiomyopathy". Tex Heart Inst J. 40 (4): 462–4. PMC 3783132. PMID 24082380.

[pmid9001809-2] Fukao T, Sakai S, Shimozawa N, Kuwahara T, Kano M, Goto E; et al. (1996). "Life-threatening cardiac involvement throughout life in a case of Costello syndrome". Clin Genet. 50 (4): 244–7. PMID 9001809.

[pmid18386622-3] Adam T, Alexandrescu L, Voinea F, Toringhibel M, Hâncu A (2006). "Fabry's disease". Rom J Intern Med. 44 (4): 455–64. PMID 18386622.

[pmid12417527-4] Jauslin ML, Wirth T, Meier T, Schoumacher F (2002). "A cellular model for Friedreich Ataxia reveals small-molecule glutathione peroxidase mimetics as novel treatment strategy". Hum Mol Genet. 11 (24): 3055–63. PMID 12417527.

[pmid17603429-5] Halawa A, Iskandar SB, Brahmbhatt V, Fahrig SA (2007). "Atrial flutter and myotonic dystrophy in a male adolescent treated with radiofrequency catheter ablation". Rev Cardiovasc Med. 8 (2): 118–22. PMID 17603429.

[pmid24534818-6] Prendiville TW, Gauvreau K, Tworog-Dube E, Patkin L, Kucherlapati RS, Roberts AE; et al. (2014). "Cardiovascular disease in Noonan syndrome". Arch Dis Child. 99 (7): 629–34. doi:10.1136/archdischild-2013-305047. PMID 24534818.

[pmid24530811-7] Tucci S, Flögel U, Hermann S, Sturm M, Schäfers M, Spiekerkoetter U (2014). "Development and pathomechanisms of cardiomyopathy in very long-chain acyl-CoA dehydrogenase deficient (VLCAD(-/-)) mice". Biochim Biophys Acta. 1842 (5): 677–85. doi:10.1016/j.bbadis.2014.02.001. PMID 24530811.

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