Quinapril hydrochloride and hydrochlorothiazide tablet
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
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Overview
Quinapril hydrochloride and hydrochlorothiazide tablet is a diuretic that is FDA approved for the treatment of is indicated for the treatment of hypertension. Common adverse reactions include shock, accidental injury, neoplasm, cellulitis, ascites, generalized edema, hernia and anaphylactoid reaction, bradycardia, cor pulmonale, vasculitis, and deep thrombosis, gastrointestinal carcinoma, cholestatic jaundice, hepatitis, esophagitis, vomiting, diarrhea, acute myopia and acute angle closure glaucoma, anemia, weight loss, myopathy, myositis, arthritis, paralysis, hemiplegia, speech disorder, abnormal gait, meningism, amnesia, pneumonia, asthma, respiratory infiltration, lung disorder, urticaria, macropapular rash, petechiases, abnormal vision, kidney function abnormal, albuminuria, pyuria, hematuria, and nephrosis..
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet FDA-Labeled Indications and Dosage (Adult) in the drug label.
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Quinapril hydrochloride and hydrochlorothiazide tablet in adult patients.
Non–Guideline-Supported Use
There is limited information regarding Off-Label Non–Guideline-Supported Use of Quinapril hydrochloride and hydrochlorothiazide tablet in adult patients.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet FDA-Labeled Indications and Dosage (Pediatric) in the drug label.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Quinapril hydrochloride and hydrochlorothiazide tablet in pediatric patients.
Non–Guideline-Supported Use
There is limited information regarding Off-Label Non–Guideline-Supported Use of Quinapril hydrochloride and hydrochlorothiazide tablet in pediatric patients. Quinapril monotherapy has been evaluated for safety in 4960 patients. In clinical trials adverse events which occurred with quinapril were also seen with ACCURETIC. In addition, the following were reported for quinapril at an incidence >0.5%: depression, back pain, constipation, syncope, and amblyopia.
Contraindications
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet Contraindications in the drug label.
Warnings
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet Warnings' in the drug label.
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet Clinical Trials Experience in the drug label.
Postmarketing Experience
BODY AS A WHOLE
- Shock, accidental injury, neoplasm, cellulitis, ascites, generalized edema, hernia and anaphylactoid reaction.
CARDIOVASCULAR SYSTEM
- Bradycardia, cor pulmonale, vasculitis, and deep thrombosis.
DIGESTIVE SYSTEM
- Gastrointestinal carcinoma, cholestatic jaundice, hepatitis, esophagitis, vomiting, and diarrhea.
EYE DISORDERS
- Acute myopia and acute angle closure glaucoma.
HEMIC SYSTEM
- Anemia.
METABOLIC AND NUTRITIONAL DISORDERS
- Weight loss.
MUSCULOSKELETAL SYSTEM
- Myopathy, myositis, and arthritis.
NERVOUS SYSTEM
- Paralysis, hemiplegia, speech disorder, abnormal gait, meningism, and amnesia.
RESPIRATORY SYSTEM
- Pneumonia, asthma, respiratory infiltration, and lung disorder.
SKIN AND APPENDAGES
- Urticaria, macropapular rash, and petechiases.
SPECIAL SENSES
- Abnormal vision.
UROGENITAL SYSTEM
- Kidney function abnormal, albuminuria, pyuria, hematuria, and nephrosis.
Hydrochlorothiazide has been extensively prescribed for many years, but there has not been enough systematic collection of data to support an estimate of the frequency of the observed adverse reactions. Within organ-system groups, the reported reactions are listed here in decreasing order of severity, without regard to frequency.
Drug Interactions
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet Drug Interactions in the drug label.
Use in Specific Populations
Pregnancy
Pregnancy Category (FDA):
There is no FDA guidance on usage of Quinapril hydrochloride and hydrochlorothiazide tablet in women who are pregnant.
Pregnancy Category (AUS):
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Quinapril hydrochloride and hydrochlorothiazide tablet in women who are pregnant.
Labor and Delivery
There is no FDA guidance on use of Quinapril hydrochloride and hydrochlorothiazide tablet during labor and delivery.
Nursing Mothers
There is no FDA guidance on the use of Quinapril hydrochloride and hydrochlorothiazide tablet in women who are nursing.
Pediatric Use
There is no FDA guidance on the use of Quinapril hydrochloride and hydrochlorothiazide tablet in pediatric settings.
Geriatic Use
There is no FDA guidance on the use of Quinapril hydrochloride and hydrochlorothiazide tablet in geriatric settings.
Gender
There is no FDA guidance on the use of Quinapril hydrochloride and hydrochlorothiazide tablet with respect to specific gender populations.
Race
There is no FDA guidance on the use of Quinapril hydrochloride and hydrochlorothiazide tablet with respect to specific racial populations.
Renal Impairment
There is no FDA guidance on the use of Quinapril hydrochloride and hydrochlorothiazide tablet in patients with renal impairment.
Hepatic Impairment
There is no FDA guidance on the use of Quinapril hydrochloride and hydrochlorothiazide tablet in patients with hepatic impairment.
Females of Reproductive Potential and Males
There is no FDA guidance on the use of Quinapril hydrochloride and hydrochlorothiazide tablet in women of reproductive potentials and males.
Immunocompromised Patients
There is no FDA guidance one the use of Quinapril hydrochloride and hydrochlorothiazide tablet in patients who are immunocompromised.
Administration and Monitoring
Administration
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet Administration in the drug label.
Monitoring
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet Monitoring in the drug label.
IV Compatibility
There is limited information regarding the compatibility of Quinapril hydrochloride and hydrochlorothiazide tablet and IV administrations.
Overdosage
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.
Pharmacology
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet Pharmacology in the drug label.
Mechanism of Action
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet Mechanism of Action in the drug label.
Structure
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet Structure in the drug label.
Pharmacodynamics
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet Pharmacodynamics in the drug label.
Pharmacokinetics
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet Pharmacokinetics in the drug label.
Nonclinical Toxicology
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet Nonclinical Toxicology in the drug label.
Clinical Studies
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet Clinical Studies in the drug label.
How Supplied
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet How Supplied in the drug label.
Storage
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet Storage in the drug label.
Images
Drug Images
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Package and Label Display Panel
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Patient Counseling Information
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet Patient Counseling Information in the drug label.
Precautions with Alcohol
Alcohol-Quinapril hydrochloride and hydrochlorothiazide tablet interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
Brand Names
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet Brand Names in the drug label.
Look-Alike Drug Names
There is limited information regarding Quinapril hydrochloride and hydrochlorothiazide tablet Look-Alike Drug Names in the drug label.
Drug Shortage Status
Price
References
The contents of this FDA label are provided by the National Library of Medicine.