Minimal change disease laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, Serge Korjian

Overview

Laboratory findings in minimal change disease include elevated hematocrit, pseudohyponatremia, hypocalcemia, and abnormal lipid panel. Findings of urine analysis include elevated urinary specific gravity, proteinuria that might reach nephrotic range, high urinary protein-creatinine ratio, microscopic hematuria, and lipid-laden cells.

Laboratory Findings

Blood

• Elevated hematocrit due to volume contraction
• Serum electrolytes may show pesudohyponatremia, defined as low serum sodium levels due to elevated serum lipids
• Hypocalcemia
• Hypovitaminosis D
• Normal/elevated serum creatinine
• Hypoalbuminemia
• Abnormal lipid profile (total cholesterol, LDL-C, HDL-C, triglycerides)
• ANA panel is usually normal
• Complement levels are usually normal

Urine

24-hour urinary analysis is indicated in the work-up of minimal change disease.

• Elevated urinary specific gravity
• Proteinuria that might reach nephrotic range
• High urinary protein-creatinine ratio
• Microscopic hematuria
• Lipid-laden cells