Endometrial cancer differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shankar Kumar, M.B.B.S. [2]]

Differentiating Endometrial Cancer From Other Diseases

• In early disease, uterine cancer must be differentiated from other diseases causing endometrial thickening:

• benign endometrial proliferation
• endometrial hyperplasia
• endometrial polyp
• submucosal uterine leiomyoma

• Differential considerations for advanced lesions include:

• uterine sarcoma(s)

• endometrial stromal sarcoma (ESS)
• leiomyosarcoma of the uterus
• malignant mixed Mullerian tumour (MMMT) of the uterus

• uterine lymphoma: rare

• primary uterine lymphoma
• secondary uterine involvement with lymphoma

• cervical cancer with uterine invasion
• metastasis to the uterus from a non gynaecologcial malignancy: rare

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