Hemophilia epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
The prevalence of hemophilia is estimated to be 20,000 cases annually. The incidence of hemophilia is estimated to be 1 in every 10,000 births( or 1 in 5,000 male births) for hemophilia A and 1 in 50,000 births for hemophilia B.
Epidemiology and Demographics
Prevalence
Currently, about 20,000 males in the United States are living with the disorder. Currently, the number of people with hemophilia in the United States is estimated to be about 20,000, based on expected births and deaths since 1994. Haemophilia A accounts for around 80% of cases. Haemophilia B (also known as Christmas disease) accounts for the remaining 20% of cases and results from a deficiency of coagulation Factor IX.[1]
Incidence
Each year, about 400 babies are born with the disorder in United States. Haemophilia usually occurs in males and less often in females. Haemophilia is rare, with only about 1 instance in every 10,000 births (or 1 in 5,000 male births) for haemophilia A and 1 in 50,000 births for haemophilia B. The incidence of Haemophilia B is around 1 in 25,000 male births. Haemophilia C (also known as plasma thromboplastin antecedent (PTA) deficiency or Rosenthal syndrome) is the fourth most common coagulation disorder after von Willebrand's disease and haemophilia A and B. In the USA it is thought to affect 1 in 100,000 of the adult population, making it 10% as common as haemophilia A.[2]
Race
Hemophilia affects people from all racial and ethnic groups. However Hemophilia C predominantly occurs in Jews of Ashkenazi descent.
Gender
Hemophilia A and B occurs more often in males and less often in females. Hemophilia C is mild form of Hemophilia affecting both sexes equally.