Endometrial cancer classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Endometrial cancer may be classified according to histology into 7 subtypes: endometrioid, uterine papillary serous, mucinous, clear cell, squamous cell, mixed and undifferentiated.
Classification
- Endometrial cancers are classified in one of the following two categories:
- Type 1 may arise from complex atypical hyperplasia and is pathogenetically linked to unopposed estrogenic stimulation.
- Type 2 develops from atrophic endometrium and is not linked to hormonally driven pathogenesis.
Cellular Classification of Endometrial Cancer
- 1. Endometrioid (75%–80%).[The most common endometrial cancer cell type is endometrioid adenocarcinoma, which is composed of malignant glandular epithelial elements]
- Ciliated adenocarcinoma
- Secretory adenocarcinoma
- Papillary or villoglandular
- Adenocarcinoma with squamous differentiation
- Adenoacanthoma
- Adenosquamous.[Adenosquamous tumors contain malignant elements of both glandular and squamous epithelium]
- 2. Uterine papillary serous (<10%)
- 3. Mucinous (1%)
- 4. Clear cell (4%)
- 5. Squamous cell (<1%)
- 6. Mixed (10%)
- 7. Undifferentiated
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Endometrial stromal sarcoma
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Malignant mixed müllerian tumor
