Rhabdomyosarcoma natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Common complication of rhabdomyosarcoma include metastasis to lung, bone marrow, and bone. Rhabdomyosarcoma is associated with a 5 year survival rate of 72%. The presence of metastasis is associated with a particularly poor prognosis. The embryonal type rhabdomyosarcoma is associated with the most favorable prognosis. Orbital and genitourinary tract rhabdomyosarcomas have the most favorable prognosis.

Complications

• Rhabdomyosarcoma may cause metastasis to other organs.
• Lung is the most common location for metastatic disease.
• Other common sites of metastasis are bone marrow and bones.

Prognosis

• Rhabdomyosarcoma is associated with a 5 year survival rate of 72%.
• The presence of metastasis is associated with a particularly poor prognosis among patients with rhabdomyosarcoma. The 5 year event free survival rate is less than 30%.
• Embryonal type rhabdomyosarcoma is associated with the most favorable prognosis.
• Prognosis varies with location of tumor- orbital and genitourinary tract rhabdomyosarcomas have the most favorable prognosis.