Glioblastoma multiforme classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Glioblastoma may be classified into several subtypes based on origin and molecular alterations.[1] [2]
Classification
Glioblastoma may be classified into two groups: Primary and secondary.[2]
1. Primary glioblastoma
- De novo origin
- More aggressive
- Occurs in older patients
2. Secondary glioblastoma
- Arises from pre-existing lower grade gliomas
- Less aggressive
- Occurs in younger patients
References
- ↑ Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD; et al. (2010). "Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1". Cancer Cell. 17 (1): 98–110. doi:10.1016/j.ccr.2009.12.020. PMC 2818769. PMID 20129251.
- ↑ 2.0 2.1 Classification of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma