Nasopharyngeal carcinoma pathophysiology

	Nasopharyngeal carcinoma Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Nasopharyngeal carcinoma from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Interventions
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Nasopharyngeal carcinoma pathophysiology On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Nasopharyngeal carcinoma pathophysiology All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Nasopharyngeal carcinoma pathophysiology
CDC on Nasopharyngeal carcinoma pathophysiology
Nasopharyngeal carcinoma pathophysiology in the news
Blogs on Nasopharyngeal carcinoma pathophysiology
Directions to Hospitals Treating Nasopharyngeal carcinoma
Risk calculators and risk factors for Nasopharyngeal carcinoma pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]

Pathophysiology

Features:^[2]

Prominent lymphoid component - key feature.
Features of squamous cell carcinoma:
- Cohesive cells with:
  - Abundant dense eosinophilic cytoplasm.
  - Central nuclei +/- small/indistinct nucleoli.

www:

World Health Classification (2005) for NPC:^[3]

Type	Histology	Description	EBV	Prevalence	Prognosis
1	keratinizing SCC	graded poorly-well-diff.	-ve	?	bad
2a	nonkeratinizing carcinoma, differentiated	well def. cell borders & tumour nest borders, mimics appearance of UCC	+ve	?	good
2b	nonkeratinizing carcinoma, undifferentiated	sheets/syncytial, vescicular nuclei, prominent nucleoli, pink cytoplasm	?	most common	?
3	basaloid SCC	mimics BCC - see basaloid SCC	?	least common	?

↑ Abdel Khalek Abdel Razek, A.; King, A. (2012). "MRI and CT of nasopharyngeal carcinoma". AJR Am J Roentgenol. 198 (1): 11–8. doi:10.2214/AJR.11.6954. PMID 22194474. Unknown parameter |month= ignored (help)
↑ Template:Ref Klatt
↑ Template:Ref WMSP
↑ Gulley ML, Nicholls JM, Schneider BG, Amin MB, Ro JY, Geradts J (1998). "Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product". Am. J. Pathol. 152 (4): 865–9. PMC 1858242. PMID 9546345. Unknown parameter |month= ignored (help)