Glioblastoma multiforme surgery
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Glioblastoma multiforme Microchapters |
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Glioblastoma multiforme surgery On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Surgery is the mainstay of treatment for glioblastoma.[1]
Surgery
Surgery is the mainstay of treatment for glioblastoma.[1]
- An average glioblastoma tumor contains 1011 cells, which is reduced to 109 cells after surgery (a reduction of 99%).
- It is used to take a section for a pathological diagnosis, to remove some of the symptoms of a large mass pressing against the brain, to remove tumor before secondary resistance to radiotherapy and chemotherapy, and to prolong survival.
- Greater the extent of tumor removal, better the prognosis. Removal of 98% or more of the tumor has been associated with a significantly longer healthier time.
- The chances of near-complete initial removal of the tumor can be greatly increased if the surgery is guided by a fluorescent dye, known as 5-aminolevulinic acid.
- Glioblastoma tumor cells are widely infiltrative through the brain at diagnosis, and so despite a "total resection" of all obvious tumor, most people with glioblastoma later develop recurrence, either at the original site or at more distant "satellite lesions" within the brain.
References
- ↑ 1.0 1.1 Treatment of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma