Gliomatosis cerebri classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Gliomatosis cerebri may be classified into two subtypes:^[1]^[2]

Type 1: no discrete mass
- No pre-existing primary cerebral neoplastic lesion
- More common
Type 2: discrete mass with diffuse CNS involvement
- Pre-existing cerebral neoplasm progress and infiltrate other cerebral lobes.
- IDH1 mutation is more common in this subtype
- Less common


Type of gliomatosis cerebri	Characteristic features

Type 1	No discrete mass No pre-existing primary cerebral neoplastic lesion More common
Type 2	Discrete mass with diffuse CNS involvement Pre-existing cerebral neoplasm progress and infiltrate other cerebral lobes. Less common IDH1 mutation is more common in this subtype

↑ Classification of gliomatosis cerebri. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/gliomatosis-cerebri
↑ Brandão RA, de Carvalho GT, de Azeredo Coutinho CA, Christo PP, Santiago CF, Santos Mdo C; et al. (2011). "Gliomatosis cerebri: diagnostic considerations in three cases". Neurol India. 59 (1): 122–5. doi:10.4103/0028-3886.76892. PMID 21339680.