Insulinoma historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Pancreatic islet cells was first described by Paul Langerhans in 1869, while he was still a medical student. Insulin was first discovered by Frederick Banting and Charles Best in 1922 from a dog’s pancreas. In 1927, William J Mayo was the first to discover the association between hyperinsulinism and a functional pancreatic islet cell tumor. In 1929, Roscoe Graham was the first to perform surgical cure of an islet cell tumor.
Insulinoma
- Pancreatic islet cells was first described by Paul Langerhans in 1869, while he was still a medical student.
- Insulin was first discovered by Frederick Banting and Charles Best in 1922 from a dog’s pancreas.
- In 1927, William J Mayo was the first to discover the association between hyperinsulinism and a functional pancreatic islet cell tumor.
- In 1929, Roscoe Graham was the first to perform surgical cure of an islet cell tumor.[1]
- Hypoglycemia was first recognized in the 19th century. In the 1920s, after the discovery of insulin and its use in the treatment of diabetics, hyperinsulinism was suspected to be a cause of hypoglycemia in non-diabetics.[2]
- A pioneering description of hyperinsulinism as a cause of hypoglycemia was published by Seale Harris in 1924.[2]
- The first report of a surgical cure of hypoglycemia by removing an islet cell tumour was in 1929.[2]
References
- ↑ Murray PD, McKenzie DT, Swain SL, Kagnoff MF (1987). "Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression". J Immunol. 139 (8): 2669–74. PMID 3498768.
- ↑ 2.0 2.1 2.2 Insulinoma. Wikipedia. https://en.wikipedia.org/wiki/Insulinoma