Hepatoblastoma pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]
Overview
Pathophysiology
Genetics
Genes involved in the pathogenesis of hepatoblastoma include:[1]
Gross Pathology
Microscopic Pathology
On microscopic histopathological analysis, hepatoblastoma is characterized by:
- Small round cell tumour.
- Fetal hepatocytes ~ 1:3 NC ratio, eosinophilic cytoplasm.
- +/- Mesenchymal component
- Immature fibrous tissue, osteoid or cartilage.
References
- ↑ Jia, Deshui; Dong, Rui; Jing, Ying; Xu, Dan; Wang, Qifeng; Chen, Lei; Li, Qigen; Huang, Yuping; Zhang, Yuannv; Zhang, Zhenfeng; Liu, Li; Zheng, Shan; Xia, Qiang; Wang, Hongyang; Dong, Kuiran; He, Xianghuo (2014). "Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex". Hepatology. 60 (5): 1686–1696. doi:10.1002/hep.27243. ISSN 0270-9139.