Hepatoblastoma natural history
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Hepatoblastoma Microchapters |
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Hepatoblastoma natural history On the Web |
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Risk calculators and risk factors for Hepatoblastoma natural history |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2] Nawal Muazam M.D.[3]
Overview
Natural History
Hepatoblastoma tends to grow rapidly. If left untreated, patients with hepatoblastoma may progress to develop failure to thrive, weight loss, rapidly enlarging abdominal mass, spontaneous rupture, hemorrhage and death.[1]
Complications
Paraneoplastic features of hepatoblastoma are not uncommon at presentation and include:[1]
- Erythrocytosis
- Thrombocytosis
- Hypocalcaemia
- Isosexual precocious puberty
- Hypoglycaemia
Prognosis
- The 5-year survival rate of children with hepatoblastoma is approximately 70%.[2]
- The table below lists prognosis of hepatoblastma based on staging:[3]
| Subtype | Description |
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| Stage I |
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| Stage II |
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| Stage III |
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| Stage IV |
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Factors that Affect Prognosis (chance of recovery) and Treatment Options
- The 5-year survival rate of children with hepatoblastoma is approximately 70%.
- The prognosis (chance of recovery) and treatment options depend on the following:
- The stage of the cancer (the size of the tumor
- Whether it affects part or all of the liver
- Whether it has spread to other places in the body, such as the lungs).
- Whether the cancer can be removed completely by surgery.
- The type of liver cancer (hepatoblastoma or hepatocellular).
- Whether the cancer has just been diagnosed or has recurred.
- Prognosis may also depend on:
- Certain features of the cancer cell (determined microscopically).
- Whether the AFP blood levels go down after chemotherapy is initiated.
References
- ↑ 1.0 1.1 Madabhavi, Irappa; Patel, Apurva; Choudhary, Mukesh; Aagre, Suhas; Revannasiddaiah, Swaroop; Modi, Gaurang; Anand, Asha; Panchal, Harsha; Parikh, Sonia; Raut, Shreeniwas (2014). "Paraneoplastic Recurrent Hypoglycaemic Seizures: An Initial Presentation of Hepatoblastoma in an Adolescent Male—A Rare Entity". Case Reports in Pediatrics. 2014: 1–5. doi:10.1155/2014/104543. ISSN 2090-6803.
- ↑ Prognosis and Prognostic Factors. National Cancer Institute 2015. http://www.cancer.gov/types/liver/hp/child-liver-treatment-pdq#link/_570_toc. Accessed on October 28, 2015
- ↑ Treatment and prognosis of hepatoblastoma. Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/hepatoblastoma. Accessed on November 3, 2015