Salivary gland tumor medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Medical Therapy
| Stage | Grade | Treatment |
|---|---|---|
| Stage I major salivary gland cancer | Low-grade tumors | Surgery alone |
| Postoperative radiation therapy should be considered when the resection margins are positive | ||
| High-grade tumors | Localized high-grade salivary gland tumors that are confined to the gland in which they arise may be cured by radical surgery alone | |
| Postoperative radiation therapy may improve local control and increase survival rates for patients with high-grade tumors, positive surgical margins, or perineural invasion | ||
| Stage II major salivary gland cancer | Low-grade tumors | Surgery alone or with postoperative radiation therapy, if indicated, is appropriate |
| Chemotherapy should be considered in special circumstances, such as when radiation therapy or surgery is refused | ||
| HIgh-grade tumors | Localized high-grade salivary gland tumors that are confined to the gland in which they arise may be cured by radical surgery alone | |
| Postoperative radiation therapy may improve local control and increase survival rates for patients with high-grade tumors, positive surgical margins, or perineural invasion | ||
| Fast neutron-beam radiation therapy or accelerated hyperfractionated photon-beam schedules reportedly are more effective than conventional x-ray therapy in the treatment of patients with inoperable, unresectable, or recurrent malignant salivary gland tumors | ||
| Stage III major salivary gland cancer | Low-grade tumors | Surgery alone or with postoperative radiation therapy, if indicated, is appropriate. |
| Chemotherapy should be considered in special circumstances, such as when radiation or surgery is refused or when tumors are recurrent or nonresponsive | ||
| High-grade tumors | Patients with localized high-grade salivary gland tumors that are confined to the gland in which they arise may be cured by radical surgery alone | |
| Postoperative radiation therapy may improve local control and increase survival rates for patients with high-grade tumors, positive surgical margins, or perineural invasion | ||
| Fast neutron-beam radiation therapy or accelerated hyperfractionated photon-beam schedules have been reported to be more effective than conventional x-ray therapy in the treatment of patients with inoperable, unresectable, or recurrent malignant salivary gland tumors | ||
| Stage IV major salivary gland cancer | Standard therapy for patients with tumors that have spread to distant sites is not curative | Fast neutron-beam radiation therapy or accelerated hyperfractionated photon-beam schedules have been reported to be more effective than conventional x-ray therapy in the treatment of patients with inoperable, unresectable, or recurrent malignant salivary gland tumors |
| Recurrent major salivary gland cancer | Fast neutron-beam radiation therapy is superior to conventional radiation therapy using x-rays and may be curative in selected patients with recurrent disease |