Pseudomyxoma peritonei causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]

Overview

Pseudomyxoma peritonei is caused by a pre-existing intraperitoneal mucinous neoplasm. The K-Ras and p53 genes may be involved in the oncogenesis.

Causes

  • Since initial descriptions of pseudomyxoma peritonei as a syndrome in association with an ovarian tumor or an appendiceal mucocele, a pre-existing intraperitoneal mucinous neoplasm has been implicated as the primary cause of pseudomyxoma peritonei.
  • Emerging evidence supports the appendiceal rather than ovarian origin of the disease.[1]
  • The primary tumor appears to arise from the MUC2 expressing goblet cells and most commonly from these cells in the appendix.
  • The K-Ras and p53 genes may be involved in the oncogenesis. It may be diagnosed with a range of conditions.
  • While the majority of pseudomyxoma peritonei are associated with appendiceal carcinomas,[2] other conditions may also be found, including disseminated peritoneal adenomucinosis (DPAM), peritoneal carcinomas, or several mucinous tumors (mucinous adenocarcinoma, mucinous cystadenoma, and mucinous cystadenocarcinoma).[3]

References

  1. Amini, Afshin; Masoumi-Moghaddam, Samar; Ehteda, Anahid; Morris, David (2014). "Secreted mucins in pseudomyxoma peritonei: pathophysiological significance and potential therapeutic prospects". Orphanet Journal of Rare Diseases. 9 (1): 71. doi:10.1186/1750-1172-9-71. ISSN 1750-1172.
  2. Young R (2004). "Pseudomyxoma peritonei and selected other aspects of the spread of appendiceal neoplasms". Semin Diagn Pathol. 21 (2): 134–50. doi:10.1053/j.semdp.2004.12.002. PMID 15807473.
  3. Jacquemin G, Laloux P (2005). "Pseudomyxoma peritonei: review on a cluster of peritoneal mucinous diseases". Acta Chir Belg. 105 (2): 127–33. PMID 15906901.


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