Atypical teratoid rhabdoid tumor surgery

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Surgery plays a critical role in obtaining tissue to make an accurate diagnosis. Surgery alone is not curative. In addition, 30% of the AT/RTs are located supratentorially and there is a predilection for the cerebello-pontine angle[1] which makes surgical resection difficult. One-third or more children will have disseminated disease at the time of diagnosis. Total or near-total resections are often not possible.

Surgery

  • Surgery is the mainstay of treatment for atypical teratoid rhabdoid tumor.[2]
  • Surgery plays a critical role in obtaining tissue to make an accurate diagnosis. Surgery alone is not curative.
  • In addition, 30% of the atypical teratoid rhabdoid tumors are located supratentorially and there is a predilection for the cerebello-pontine angle, which makes surgical resection difficult. One-third or more children will have disseminated disease at the time of diagnosis. Total or near-total resections are often not possible.[3]

Stem Cell Transplantation

  • Stem cell transplantation is indicated in very aggressive atypical teratoid rhabdoid tumors, to receive high doses of chemotherapy.[4]

References

  1. [http://www.utmb.edu/otoref/Grnds/Mass-CPA-040602/Mass-CPA-slides-040602.pdf PDF
  2. Ginn, Kevin F.; Gajjar, Amar (2012). "Atypical Teratoid Rhabdoid Tumor: Current Therapy and Future Directions". Frontiers in Oncology. 2. doi:10.3389/fonc.2012.00114. ISSN 2234-943X.
  3. [http://www.utmb.edu/otoref/Grnds/Mass-CPA-040602/Mass-CPA-slides-040602.pdf PDF
  4. Treatment and care options of atypical teratoid rhabdoid tumor. Dana-Farber and Boston Children hospital cancer and blood disorder center 2015. http://www.danafarberbostonchildrens.org/conditions/brain-tumor/atypical-teratoid-rhabdoid-tumor.aspx. Accessed on December 21, 2015

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