Sandbox: Kaposi

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Clincal Stage Histologic Features

Macular stage

Thin-walled, angulated vessels throughout dermis, with hemosiderin and plasma cell infiltrate

Patch stage

Angulated lumina that dissect dermal collagen Vessels may proliferate around well-developed round venules (premonitory sign) Angiomatoid vascular spaces with red blood cells are surrounded by spindle cells in short fascicles

Tumor stage

Solid nodules with extensive spindle cells and red blood cells in slit-like lumina No/rare mitotic activity or atypia

Lymphangioma-like variant

Thin, angulated vessels with no red blood cells