Kaposi's sarcoma laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Kaposi's sarcoma Microchapters
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Overview
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Differentiating Kaposi's sarcoma from other Diseases
Epidemiology and Demographics
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Overview

Although KS may be suspected from the appearance of lesions and the patient's risk factors, a definite diagnosis can only be made by biopsy and microscopic examination, which will show the presence of spindle cells. Detection of the viral protein LANA in tumor cells confirms the diagnosis.

Laboratory Findings

Complete Blood Count

• Decreased hemoglobin level

Electrophoresis

• Detect antibodies against KSHV

ELISA

• Screens for HIV infection among Kaposi's sarcoma patients

Western Blot

• Confirms HIV infection among Kaposi's sarcoma patients

Immunohistochemistry

• Kaposi's sarcoma cells are typically CD34, HHV-8, and D2-40 positive