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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Causes
Chondromyxoid Fibroma
There are no established causes for chondromyxoid fibroma. However, scientists have noted an association of chondromyxoid fibroma with certain chromosomal abnormalities. Chondromyxoid fibroma may be caused by a clonal rearrangement of chromosome 6. The oncogene activation resulting from this clonal rearrangement is likely to be involved in the pathogenesis of chondromyxoid fibroma. Scientists have found that the glutamate receptor gene GRM1 recombines with several partner genes through promoter swapping and gene fusion. The subjects with chondromyxoid fibroma also showed increases in GRM1 gene expression levels.[1][2][3]
References
- ↑ Granter SR, Renshaw AA, Kozakewich HP, Fletcher JA (1998). "The pericentromeric inversion, inv (6)(p25q13), is a novel diagnostic marker in chondromyxoid fibroma". Mod Pathol. 11 (11): 1071–4. PMID 9831204.
- ↑ Yasuda T, Nishio J, Sumegi J, Kapels KM, Althof PA, Sawyer JR; et al. (2009). "Aberrations of 6q13 mapped to the COL12A1 locus in chondromyxoid fibroma". Mod Pathol. 22 (11): 1499–506. doi:10.1038/modpathol.2009.101. PMC 2784180. PMID 19648885.
- ↑ Nord KH, Lilljebjörn H, Vezzi F, Nilsson J, Magnusson L, Tayebwa J; et al. (2014). "GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma". Nat Genet. 46 (5): 474–7. doi:10.1038/ng.2927. PMID 24658000.