Mumps virus

style="background:#Template:Taxobox colour;"\|Template:Taxobox name
	; TEM micrograph of the mumps virus.
style="background:#Template:Taxobox colour;" \| Virus classification
Group:	Group V ((-)ssRNA)
Order:	Mononegavirales;
Family:	Paramyxoviridae;
Genus:	Rubulavirus;
Type species
	Mumps virus;

	Mumps Microchapters
Home
Patient Information
Overview
Historical Perspective
Pathophysiology
Causes
Differentiating Mumps from other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Criteria
History and Symptoms
Physical Examination
Laboratory Findings
CT
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Mumps virus On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Mumps virus All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Mumps virus
CDC on Mumps virus
Mumps virus in the news
Blogs on Mumps virus
Directions to Hospitals Treating Mumps
Risk calculators and risk factors for Mumps virus

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Lakshmi Gopalakrishnan, M.B.B.S. [2]

Overview

Mumps is caused by a paramyxovirus, and transmission of the virus occurs via respiratory secretions such as infected saliva, air droplets or via direct contact with articles that have been contaminated with infected saliva. The incubation period is usually 18 to 21 days. Infected patients remain contagious from approximately 6 days before the onset of symptoms until about 9 days after the onset of symptoms.

Organism

Mumps virus (MuV) is an enveloped, non-segmented, negative-sense RNA virus that causes mumps.
MuV belongs to the genus Rubulavirus and family Paramyxovirus.

Morphology

The spherical virion is approximately 200nm is diameter and its genome consists of a single RNA strand of 15,384 nucleotides.^[1]
The RNA is encapsidated by nucleoprotein (N protein) forming the ribonucleoprotein (RNP) complex.

Replication Cycle

MuV binds to host cell sialic acid via haemagglutinin-neuraminidase (HN) and fusion (F) glycoproteins and cause virus-to-cell membrane fusion.
Replication and transcription is mediated by an RNA polymerase complex composed of large (L) and phospho- (P) proteins.
Budding is initiated after HN and F glycoproteins are transported through the endoplasmic reticulum and Golgi body to the cell surface.
Matrix (M) protein localizes the RNP to the area of the host cell expressing HN and F.

Human Pathogen

Humans are the only natural host of MuV.
- MuV is able to evade an immune response to infection with the following virulence factors:

Small hydrophobic (SH) protein is presumed to block TNFα-mediated apoptosis.^[2]
Non-structural proteins NS1 and NS2 (V proteins) inhibit IFN production and signaling.^[3]

Related Chapters

Paramyxovirus

References

↑ Hviid A, Rubin S, Mühlemann K (March 2008). "Mumps". The Lancet. 371 (9616): 932–44. doi:10.1016/S0140-6736(08)60419-5. PMID 18342688.
↑ He B, Lin GY, Durbin JE, Durbin RK, Lamb RA (2001). "The SH integral membrane protein of the paramyxovirus simian virus 5 is required to block apoptosis in MDBK cells". J Virol. 75 (9): 4068–79. doi:10.1128/JVI.75.9.4068-4079.2001. PMC 114152. PMID 11287556.
↑ Andrejeva J, Childs KS, Young DF, Carlos TS, Stock N, Goodbourn S; et al. (2004). "The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter". Proc Natl Acad Sci U S A. 101 (49): 17264–9. doi:10.1073/pnas.0407639101. PMC 535396. PMID 15563593.

Template:WikiDoc Sources

[Hviid2008-1] Hviid A, Rubin S, Mühlemann K (March 2008). "Mumps". The Lancet. 371 (9616): 932–44. doi:10.1016/S0140-6736(08)60419-5. PMID 18342688.

[pmid11287556-2] He B, Lin GY, Durbin JE, Durbin RK, Lamb RA (2001). "The SH integral membrane protein of the paramyxovirus simian virus 5 is required to block apoptosis in MDBK cells". J Virol. 75 (9): 4068–79. doi:10.1128/JVI.75.9.4068-4079.2001. PMC 114152. PMID 11287556.

[pmid15563593-3] Andrejeva J, Childs KS, Young DF, Carlos TS, Stock N, Goodbourn S; et al. (2004). "The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter". Proc Natl Acad Sci U S A. 101 (49): 17264–9. doi:10.1073/pnas.0407639101. PMC 535396. PMID 15563593.

[1]

[2]

[3]