Hamman-Rich syndrome laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chandrakala Yannam, MD [2]

Overview

There are no diagnostic laboratory findings associated with acute interstitial pneumonitis. However, useful laboratory findings consistent with the diagnosis of acute interstitial pneumonitis include abnormal arterial blood gases, physiologic lung testing, complete blood count, bronchoalveolar lavage, bronchoscopy and surgical lung biopsy.

Laboratory findings

Laboratory findings consistent with the diagnosis of acute interstitial pneumonitis include:

• Abnormal ABG
  • May indicate hypoxia, hypercapnia, and respiratory acidosis
• Peak flow assessment
  • May be below normal range which is 100 liters/minute for men, and 80 liters/minute for women
• Spirometry
  • May indicate a restrictive pulmonary disease
  • A FEV1/FVC ratio > 80% indicates restrictive disease
• CBC
  • May indicate anemia, neutrophilia, elevated ESR, elevated CRP, and elevated immunoglobulin
• Abnormal sputum analysis
  • May contain bacteria, such as mycobacterium tuberculosis or inorganic particles, such as asbestos bodies or organic particles