Hypocalcemia classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

There is a functional classification of hypocalcemia which includes complete absent of PTH gland, PTH insufficiency and PTH overactivity.

Classification

• Hypocalcemia may be classified functionally into following subtypes:

Absence of PTH

• Absence of PTH is primarily seen in
  • Hereditary hypoparathyroidism
  • Acquired hypoparathyroidism
  • Hypomagnesemia

PTH Insufficiency

• PTH insufficiency is seen in active vitamin D lacking which is seen in
  • Dietary intake
  • Insufficient exposure to sunlight
  • Vitamin D-dependent rickets type 1
  • Chronic renal failure
• PTH insufficiency is seen in active vitamin D ineffectiveness which is seen in
  • Intestinal malabsorption
  • Vitamin D-dependent rickets type 2
  • Pseudoparathyroidism

PTH Overwhelmed

• PTH overactivity which is seen in
  • Severe hypophosphatemia
  • Tumor Lysis syndrome
  • Acute renal failure
  • Rhabdomyolysis