Sickle-cell disease risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shyam Patel [2]

Risk Factors

Besides race, there are no specific risk factors for sickle cell disease. Sickle cell disease is a monogenetic disease, meaning that one gene mutations causes the disease. Thus environmental factors do not play a major role in acquisition of the disease. The disease occurs at birth after a person inherits 2 sickle cell alleles, one from each parent. Certain endemic regions contain a high prevalence of sickle cell alleles.

There are some risk factors for precipitation of sickle cell crises, such as dehydration, low oxygen levels, medication nonadherence.