Sickle-cell disease risk factors
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shyam Patel [2]
Overview
There are no specific risk factors for sickle cell disease.
Risk Factors
Besides race, there are no specific risk factors for sickle cell disease. Sickle cell disease is a monogenetic disease, meaning that one gene mutations causes the disease. Thus environmental factors do not play a major role in acquisition of the disease. The disease occurs at birth after a person inherits 2 sickle cell alleles, one from each parent. Certain endemic regions contain a high prevalence of sickle cell alleles.[1] The degree of fetal hemoglobin production is related to the severe of disease: higher fetal hemoglobin confers lower disease morbidity and thus is a favorable risk factor/modifier.[2]
There are some risk factors for precipitation of sickle cell crises, such as dehydration, low oxygen levels, medication nonadherence.
References
- ↑ Makani J, Ofori-Acquah SF, Nnodu O, Wonkam A, Ohene-Frempong K (2013). "Sickle cell disease: new opportunities and challenges in Africa". ScientificWorldJournal. 2013: 193252. doi:10.1155/2013/193252. PMC 3988892. PMID 25143960.
- ↑ Kutlar A, Ataga K, Reid M, Vichinsky EP, Neumayr L, Blair-Britt L; et al. (2012). "A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease". Am J Hematol. 87 (11): 1017–21. doi:10.1002/ajh.23306. PMC 3904792. PMID 22887019.