Necrotizing fasciitis risk factors

Necrotizing fasciitis Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Necrotizing fasciitis from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Criteria
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X Ray
CT
MRI
Ultrasound
Biopsy
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Future or Investigational Therapies
Case Studies
Case #1
Necrotizing fasciitis risk factors On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Necrotizing fasciitis risk factors All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Necrotizing fasciitis risk factors
CDC on Necrotizing fasciitis risk factors
Necrotizing fasciitis risk factors in the news
Blogs on Necrotizing fasciitis risk factors
Directions to Hospitals Treating Necrotizing fasciitis
Risk calculators and risk factors for Necrotizing fasciitis risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yamuna Kondapally, M.B.B.S[2]

Risk Factors

Common risk factors in the development of necrotizing fasciitis include:

Type 1	Type 2	Type 3	Type 4
• Alcoholism • Antecedent trauma • Carcinoma • Cardiopulmonay disease • Diabetes • Iatrogenic procedures • Immunosupression (e.g., HIV and corticosteroid use) • Intravenous drug abuse • Male gender • Peripheral vascular disease • Recent surgery • Smoking • Advanced age	• Alcoholism • Antecedent trauma • Carcinoma • Cardiopulmonay disease • Diabetes • Immunosupression (e.g., HIV and corticosteroid use) • Intravenous drug abuse • Male gender • Peripheral vascular disease • Recent surgery • Exposure to children with sore throat • HLA class II haplotype • Lack of specific anti-GAS antibodies • Varicella infection • Advanced age	• Raw oyster ingestion • Wound contamination with sea water • Immunosupression • Advanced age	• Immunosupression • Antecedent trauma • Burns • Advanced age

Role of NSAIDS in GASNF

• NSAIDS mask the signs and symptoms leading to delay in diagnosis of existing infection.
• NSAIDS potentiate the development of renal failure by inhibiting renal prostaglandin synthesis and prevent the respiratory burst necessary for phagocytes to kill intracellular organisms leading to impairment of natural host defense mechanisms.