Neutropenia pathophysiology

	Neutropenia Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Overview

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Neutropenia develops as a result of one of the three following mechanisms:

1) Impaired granulocyte production

- Hematologic malignancy with bone marrow infiltration

- Myelosuppressive chemotherapy or other medications that are toxic to the bone marrow

- Nutritional deficiencies

2) Margination (process where free flowing blood cells exit circulation)

- Splenic sequestration

- Adherence to the vascular endothelium

3) Peripheral destruction

- Autoimmune hemolysis

- Drug-induced hemolysis