Sickle-cell disease screening
Sickle-cell disease Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Sickle-cell disease screening On the Web |
American Roentgen Ray Society Images of Sickle-cell disease screening |
Risk calculators and risk factors for Sickle-cell disease screening |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shyam Patel [2]
Overview
Sickle cell disease is currently a disease for which newborn screening is available, mandated, and routinely performed in the United States.[1]
Screening
Screening for sickle cell disease was first offered in 1975 but had not been performed routinely.[2] By the 1980s, most states were performing newborn screening, based on evidence showing that early administration of antibiotics in patients with known sickle cell disease improved outcomes.[3] People who are known carriers of the disease often undergo genetic counseling before they have a child. A test to see if an unborn child has the disease takes either a blood sample from the unborn or a sample of amniotic fluid. Since taking a blood sample from a fetus has risks, the latter test is usually used. Currently, all 50 states in the USA require newborn screening for sickle cell disease.[1] It is important to note that there can be false-positive and false-negative results with newborn screening. This may cause overdiagnosis or underdiagnosis, respectively, of sickle-cell disease.
Screening for [disease name] by [test 1] is recommended every [duration] among patients with:
References
- ↑ 1.0 1.1 Brandow AM, Liem R (2011). ""Sickle Cell Disease in the Emergency Department: Atypical Complications and Management"". Clin Pediatr Emerg Med. 12 (3): 202–212. doi:10.1016/j.cpem.2011.07.003. PMC 3172721. PMID 21927581.
- ↑ Colah RB, Mukherjee MB, Martin S, Ghosh K (2015). "Sickle cell disease in tribal populations in India". Indian J Med Res. 141 (5): 509–15. PMC 4510747. PMID 26139766.
- ↑ Burke W, Tarini B, Press NA, Evans JP (2011). "Genetic screening". Epidemiol Rev. 33: 148–64. doi:10.1093/epirev/mxr008. PMC 3166195. PMID 21709145.