Tricuspid stenosis causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]
Overview
The most common cause of tricuspid stenosis is rheumatic heart disease. Other causes of tricuspid stenosis include carcinoid syndrome, congenital abnormalities, endocarditis, lupus, and mechanical obstruction by a tumor.[1][2]
Causes
Common Causes
- Rheumatic heart disease (majority of the cases)[2]
- Carcinoid syndrome[2]
- Congenital[2]
- Rheumatic heart disease is one of the most common causes of TS and almost always occurs in conjunction with mitral stenosis.
- Large vegetations in infective endocarditis can cause relative stenosis.
- Carcinoid syndrome may cause isolated TS or mixed with the regurgitant lesion.
- Systemic diseases like systemic lupus erythematosus (SLE), antiphospholipid antibody (APLA) syndrome and the presence of permanent pacing and fusion of implantable cardioverter defibrillator leads to sub-valvular structures can cause tricuspid stenosis.
- Benign tumors like atrial myxomas can cause functional TS.
- Blunt trauma has also been described as a risk factor. Renal and ovarian tumors can grow into the tricuspid orifice causing stenosis.
- Other less common causes of TS include congenital abnormalities (Ebstein’s anomaly), metabolic or enzymatic abnormalities (Fabry’s disease, Whipple’s disease). *Sometimes described are intravenous leiomyomatosis, ventriculoatrial shunts causing TS.
- Valvulopathy associated with drugs like fenfluramine/phentermine and methysergide is characterized by thickened fibrotic and hypomobile tricuspid leaflets, with various degrees of valve stenosis and regurgitation.
Causes by Organ System
| Cardiovascular | Congenital heart disease, cardiac tumor, saphenous vein bypass graft aneurysm,[3] Ebstein's anomaly, endomyocardial fibrosis, infective endocarditis, myxoma, rheumatic heart disease |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | Methysergide |
| Ear Nose Throat | No underlying causes |
| Endocrine | Carcinoid syndrome |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | No underlying causes |
| Hematologic | No underlying causes |
| Iatrogenic | Pacemaker infection, pacemaker leads[4], device closure of right coronary arteriovenous fistula.[5] |
| Infectious Disease | Infective endocarditis |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | Fabry disease, Whipple's disease |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | Carcinoid syndrome, cardiac tumor, intravenous leiomyomatous tumor,[6] metastatic tumor, myxoma |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | Amyloidosis,[7] systemic lupus erythematosus |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | Giant blood cyst |
Causes by Alphabetical Order
- Amyloidosis[7]
- Carcinoid syndrome
- Cardiac tumor
- Congenital heart disease
- Ebstein's anomaly
- Endomyocardial fibrosis
- Fabry disease
- Giant blood cyst
- Infective endocarditis
- Intravenous leiomyomatous tumor[6]
- Metastatic tumor
- Myxoma
- Pacemaker infection
- Pacemaker leads
- Rheumatic heart disease
- Systemic lupus erythematosus
- Whipple's disease
References
- ↑ Baumgartner H, Hung J, Bermejo J, Chambers JB, Evangelista A, Griffin BP; et al. (2009). "Echocardiographic assessment of valve stenosis: EAE/ASE recommendations for clinical practice". Eur J Echocardiogr. 10 (1): 1–25. doi:10.1093/ejechocard/jen303. PMID 19065003.
- ↑ 2.0 2.1 2.2 2.3 Waller BF, Howard J, Fess S (1995). "Pathology of tricuspid valve stenosis and pure tricuspid regurgitation--Part I." Clin Cardiol. 18 (2): 97–102. PMID 7720297.
- ↑ Jellis CL, Navia JL, Flamm SD, Rodriguez LL (2016). "Severe Functional Tricuspid Stenosis Secondary to a Giant Saphenous Vein Bypass Graft Aneurysm". Circulation. 133 (21): 2099–102. doi:10.1161/CIRCULATIONAHA.115.014772. PMID 27217436 PMID: 27217436 Check
|pmid=value (help). - ↑ Taira K, Suzuki A, Fujino A, Watanabe T, Ogyu A, Ashikawa K (2006). "Tricuspid valve stenosis related to subvalvular adhesion of pacemaker lead: a case report". J Cardiol. 47 (6): 301–6. PMID 16800373.
- ↑ Changchien C, Lin MT, Wang CC, Liu HM, Wang CC, Chiu SN; et al. (2015). "Neonatal tricuspid stenosis caused by device closure of a large coronary fistula". EuroIntervention. 11 (7): e1. doi:10.4244/EIJV11I7A162. PMID 26603866 PMID: 26603866 Check
|pmid=value (help). - ↑ 6.0 6.1 Nili M, Liban E, Levy MJ (1982). "Tricuspid stenosis due to intravenous leiomyomatosis--a call for caution: case report and review of the literature". Tex Heart Inst J. 9 (2): 231–5. PMC 351617. PMID 15226964.
- ↑ 7.0 7.1 Kim KH, Park CH, Park HS, Kim YR, Choi EY (2014). "Amyloidosis-induced tricuspid stenosis mimicking rheumatic heart disease". Eur Heart J Cardiovasc Imaging. 15 (10): 1167. doi:10.1093/ehjci/jeu075. PMID 24797117.